Formulation Development Intern, Summer 2018

Location
Tarrytown, New York
Posted
Mar 20, 2018
Ref
11162BR
Required Education
Doctorate/PHD/MD
Position Type
Part time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

These positions are in Formulation Development in Tarrytown, NY. There are 3 openings for Summer 2018. Each opening is described below.

Position1: The student will be conducting research in protein solubility characterization. Protein solubility is an important thermodynamic property of a protein solution. In the biopharmaceutical industry, it is important to understand protein solubility in order to design appropriate formulations to ensure protein formulation can be manufactured successfully and with a desired long-term stability. The goal of this summer intern research project is to understand the formulation factors can impact monoclonal antibody solubility. The work will increase our knowledge with respect to monoclonal antibody solubility and contribute to developing general approaches in managing the solubility issues during formulation and process development. The internship offers a unique opportunity to gain experience in therapeutic protein drug product development. The student will not only gain hands-on experiences in protein formulation development but also establish fundamental understandings in protein solubility and stability. In addition, you will network with other interns and Scientists at Regeneron at various projects and social events throughout the summer.

Position 2: Forced degradation study is routinely performed in FDG group as per agency guideline in order to assess the potential CQAs and characterize the degradation pathways of mAbs under different stressed conditions. For a co-formulated drug product (DP), it is challenging to characterization the degradation products. In this proof-of-concept study, the student will apply various stress conditions and characterize the forced degradation products by ultra-performance liquid chromatography (UPLC) methods to analyze the protein degradation for a co-formulated DP. In addition to the regular UPLC methods, such as size exclusion chromatography (SEC), ion exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC), the student will explore the combination of liquid chromatography techniques with different separation mechanisms to characterize the degradation products of a co-formulated monoclonal DP. This work will provide detailed insight that may help elucidating the degradation pathway of a co-formulated DP.

Position 3: The student will work on a project that focuses on the characterization of protein formulations to understand formulation stability with respect to aggregation and particulates formation with biophysical and chromatographic techniques. For monoclonal antibody drug formulations, aggregates and particulates may form during manufacturing, product storage and drug delivery. The student project will explore the protein properties that may be predictive of aggregation and particulates formation. A number of protein candidates will be profiled by biophysical and chromatographic techniques. In addition the interactions between protein and contact materials used for manufacturing and drug delivery will be explored to evaluate the effect of material type on aggregation and particulate formation. The learnings from this project will further our understanding of protein aggregation mechanism and to develop predictive tools assessing the product development risk for particulate formation. The student will learn fundamentals of protein biophysical and chromatographic characterization and biologics drug product development.

Start building your skills at Regeneron.
• Projects 2, 3: Must be a PhD student, Project 1: Must be an undergraduate
• Must be pursuing a degree in Chemical Engineering, Biochemistry, Pharmaceutical Science or related
• Experience with general protein related lab skills, able to measure protein physical properties (pH, osmolality, conductivity, protein concentration, viscosity), protein filtration experience, familiar with peristaltic pump, analytical balance.
• Experience with HPLC and biophysical characterization of proteins, such as UV spectroscopy and light scattering is preferred
• Must demonstrate effective communication skills. Must have the ability to work in a team environment

General Intern Program Information:
• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
• Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid
• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
• Minimum GPA of 3.0
• You will work with a specific manager on a project(s)
• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
• Present to your team on your summer project

Transportation and Housing:
• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 11162BR