Bioassays Intern, Summer 2018

Tarrytown, New York
Mar 20, 2018
Required Education
Bachelors Degree
Position Type
Part time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

These positions are in Bioassay in Tarrytown, NY. There are 5 openings for Summer 2018. Each opening is described below.

Position 1: G-protein coupled receptors (GPCRs) are a large and diverse group of membrane receptors that interact with a variety of signaling molecules. Several GPCRs are involved in the maintenance and control of human metabolism and consequently present unique opportunities for novel therapeutics. The student will aid in the experimental characterization of in-house molecules and evaluate their functionality in physiologically relevant bioassays designed to measure GPCR activity. Assay techniques such as internalization, flow cytometry, and luminescence-based reporters will be used to identify distinctive features of the target molecule and related binding partners.

Position 2: The student will develop cell-based assays (ion channel, cytotoxicity, luciferase-based reporter assays) and convert lower throughput, 96-well assays to novel 384 well formats. Bioassays for screening drug candidates are an important component for preclinical drug development. Adapting cell-based assays to high throughput and reproducible formats is essential to the earliest stages of the drug discovery process. The student will learn about the drug discovery process, bioassay development and screening for novel therapeutics, and how to automate and miniaturize cell-based assays.

Position 3: The student will be a part of the bioassay development team and will learn proper cell culturing techniques as well as assist in the design and performance of cell-based assays to assess in-vitro efficacy of therapeutic antibodies. The student will help engineer cell lines needed for various Immuno-Oncology targets and assist in the implementation of these cell lines in various assay formats such as luciferase-based assays and primary cell based assays. The student will be taught and given the opportunity to communicate in a team setting the project outcomes. During this process the student will gain a deeper understanding of biological assays and techniques currently used to determine antibody efficacy.

Position 4: The student will focus of development of in vitro cell-based assays to characterize therapeutic antibodies during late-stage preclinical development. The primary area of focus of this internship will be to assess the propensity for cytokine release from peripheral blood mononuclear cells (PBMCs) upon treatment with antibody therapeutics. This will involve the purification of PBMCs, cell-based assay development and flow cytometry.

Position 5: The student will work on the development of cell-based assays to test the function of a therapeutic target proteins based on its mechanism of action. The co-op will learn about target biology, identifying strategies to interrogate the molecular mechanism and developing assays that can be used for testing in-vitro function of the protein to identify/characterize potential drugs. The ideal candidate is a highly motivated student with good communication skills and with interest in learning about assay design and early development.

Start building your skills at Regeneron.
• Must be an undergraduate, graduate, or PhD student
• Must be pursuing a degree in Biology or related field
• Experience with mammalian cell culture, flow cytometry, and cell-based bioassay development is preferred
• Must have completed general biology lab courses. Completion of molecular and/or cell biology labs and courses preferred.

General Intern Program Information:
• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
• Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid
• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
• Minimum GPA of 3.0
• You will work with a specific manager on a project(s)
• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
• Present to your team on your summer project

Transportation and Housing:
• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 11642BR