Founder and Special Populations Intern, Summer 2018

Location
Tarrytown, New York
Posted
Mar 20, 2018
Ref
11200BR
Discipline
Science/R&D, Genetics
Required Education
Bachelors Degree
Position Type
Part time
Position Summary

The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

The Regeneron Genetics Center is a comprehensive genomics program in which we perform high-throughput DNA sequencing in patients and strategic populations to understand human biology and to identify novel therapeutic targets. Founder populations provide great opportunities for novel gene discovery since certain gene variants may be enriched due to genetic drift and they are more likely to be present in their homozygous state due to endogamy.

These positions are in Founder and Special Populations in Tarrytown, NY. There are 3 openings for Summer 2018. Each opening is described below.

Position 1: The student will catalog drifted genetic variants from founder populations around the world. He/She will utilize results from internal analyses and databases, published literature and other publically available information to prioritize the most interesting variants and to better understand their biological consequences. Populations include the Old Order Amish, Mennonites, Ashkenazi Jews, Native American Indians, as well as several others.

Position 2: This student will focus on the genetics of founder and special populations. This may include learning and performing bioinformatics analyses to characterize the allelic architecture of the populations and derive biological insights for potential genes of interest.

Position 3: The student will be assigned to a team investigating the genetics and biological mechanisms of aging, with the goal of discovering disease-protective genetic variants involved in healthy human longevity. The student will perform comprehensive literature reviews in parallel with computational analyses to identify and define functions of longevity-associated targets. In addition, the student may help in functional validation of targets using relevant molecular and genetic techniques in the laboratory, followed by careful data analysis and interpretation. The student will be expected to present their data internally at regular meetings with project supervisors and departmental lab meetings.

Start building your skills at Regeneron.
• Must be an Undergrad student for Positions 2-3 and a PharmD student for Position 1
• Must be pursuing a degree in biology, pharmacy, genetics/genomics, bioinformatics, or computational biology
• Experience with QlikView, SQL, Scripting for position 2
• Prefer hands-on experience in either dry lab (programming, informatics, statistics) and/or wet lab (PCR, immunoblotting, cell culture) for position 3
• Must be highly motivated and intelligent with good problem solving skills. Must have the ability to navigate the internet and a basic understanding of biology and genetics for position 1

General Intern Program Information:
• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
• Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid
• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
• Minimum GPA of 3.0
• You will work with a specific manager on a project(s)
• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
• Present to your team on your summer project

Transportation and Housing:
• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 11200BR