Cardiovascular and Renal Diseases Intern, Summer 2018

Location
Tarrytown, New York
Posted
Mar 20, 2018
Ref
11729BR
Discipline
Science/R&D, Pathology
Required Education
Associate Degree
Position Type
Part time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

These positions are in Cardiovascular/Renal Diseases in Tarrytown, NY. There are 3 openings for Summer 2018. Each opening is described below.

Position 1: The student will focus on the area of blood coagulation with an emphasis on fibrinolysis (i.e., breakdown of clots). We are interested in two endogenous fibrinolytic inhibitors in the fibrinolysis pathway, so use of antagonists to either would be expected to increase the rate of fibrinolysis, thus leading to a quicker clot clearance.

The aims of the project for the student are to 1) gain an understand of the relevance of coagulation and fibrinolysis in health and disease and 2) to work closely with Research Associates to evaluate the hypothesis that inhibition of fibrinolysis inhibitors is beneficial for clot breakdown in in vitro coagulated human plasma/blood triggered by either contact activation or tissue factor activation. In addition, the student will be offered an opportunity to participate in in vivo mouse studies that evaluate how these inhibitors affect clot stability and breakdown after an induced thrombotic event. Results from this project will increase our understanding of whether prophylactic antagonism to fibrinolytic inhibitors may hold therapeutic potential in thrombophilia and stroke.

Position 2: The student will become familiar with hearing assessment in COL4A3 KO mouse model of Alport Syndrome. Patients with COL4A5 (85%, x-linked), COL4A3 and COL4A4 (15%) mutations develop kidney disease called Alport Syndrome. Majority of these patients also develop hearing loss in their lifetime. At REGN, mouse model of Alport Syndrome was developed by knocking out COL4A3 gene. The student will participate in the functional assessment of hearing as well as histopathological characterization of inner ear in this model. The student will also get a chance to get familiarize with the disease biology/pathology of Alport Syndrome as a part of the training. The student, along with a trained Research Associate, will be involved in development of methods, data analysis, documentation and presentation of the findings.

Position 3: The student will work closely with Research Associates to probe cardiovascular biology in vivo and in vitro. In vivo pharmacology and/or surgical models of disease combined with ultrasound assessment of cardiovascular function will be the focus of this project. Human iPSC-derived cardiomyocytes will be utilized for in vitro experimentation. Additional tools and techniques utilized during the course of this project will include an impedance/field potential system, calcium flux assessment, gene expression and western blotting.

Start building your skills at Regeneron.
• Must be an undergraduate student
• Must be pursuing a degree in Biology or Biomedical areas
• Experience with rodents and/or histology image analysis, ultrasound acquisition and analysis is desired, but not required

General Intern Program Information:
• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
• Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid
• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
• Minimum GPA of 3.0
• You will work with a specific manager on a project(s)
• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
• Present to your team on your summer project

Transportation and Housing:
• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 11729BR