Oncology Co-op, Summer and Fall 2018

Location
Tarrytown, New York
Posted
Mar 20, 2018
Ref
10538BR
Discipline
Science/R&D, Oncology
Required Education
Bachelors Degree
Position Type
Part time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

This project will support a bispecific ADC program within the Oncology-Angiogenesis department in Tarrytown, NY.
• Perform in vitro binding, internalization, receptor degradation and cell killing assays in cancer cell lines. This will help in the selection of tumor models in which to study the bispecific-ADC anti-tumor efficacy.
• Determine expression of the bispecific ADC targets in PDX tumors from commercial sources. This will help to identify PDX models in which to study the anti-tumor efficacy of the bispecific-ADC.
• Determine expression of one of the bispecific-ADC targets in organs harvested from humanized mice.
• Assist in the execution of an arrayed CRISPR screen aiming to elucidate the machinery responsible for the internalization of the bispecific-ADC. Particularly, perform internalization assays.
• Perform internalization assays in cells transfected with mutants of the bispecific-ADC targets. These constructs (14 already generated) bear mutations in candidate endocytic signals of the targets.
• Assist in in vivo studies (i.e. process serum samples for ADC concentration determination).

**This position is for a Co-op, 40 hrs per week in the Summer AND Fall (roughly May/June to December).

Start building your skills at Regeneron.
• Bachelors, Masters or PhD students considered
• Pursuing a degree in Biology or related major
• Cell culture, microscopy, western blot
• Animal experience a plus

General Intern/Co-op Program Information:
• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD
• Program is full-time (~40 hrs/wk) and is paid
• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community
• Minimum GPA of 3.0
• You will work with a specific manager on a project(s)
• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!
• Present to your team on your summer project

Transportation and Housing:
• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus
• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 10538BR