Senior/Principal Scientist, Translational Biology

94080, South San Francisco
Mar 12, 2018
Required Education
Position Type
Full time

Harpoon Therapeutics is an early-stage biotech company located in South San Francisco. The Company is developing biologics with novel molecular formats to engage and activate immune cells for the treatment of cancer and other diseases. We are seeking a candidate with in-depth knowledge and demonstrated achievements in developing, implementing, and applying rodent tumor models to evaluate the efficacious of experimental antitumor drugs. The successful candidate will be a leader in building a new functional area of in vivo pharmacology and the required infrastructures for Harpoon Therapeutics.


  • Lead the company’s in vivo pharmacology efforts to evaluate the antitumor activity, pharmacokinetics, and pharmacodynamics of novel drug molecules.
  • Develop, adopt, and implement various tumor models in both xenogeneic and syngeneic settings.
  • Interact with discovery research to design, prioritize, and execute in vivo experiments required for development decision and regulatory submissions.
  • Represent Translational Biology on project development teams.
  • Present experimental findings in the forms of meeting abstracts, posters, and/or manuscripts in scientific journals.
  • Author documents for regulatory submissions.
  • Ensure compliance of animal experimentation to regulatory guidelines.


  • A PhD with 3+ or a MS with 5+ years of experience in cancer biology, pharmacology, immunology, or tumor immunotherapy who demonstrates established accomplishments in the design and execution of in vivo tumor model experiments as supported by publications in peer-reviewed journals and poster presentations in major scientific conferences.
  • Hands on experience and proficiency in handling rodent species, tumor and immune cell implantation, using various experimental end-points to evaluate tumor growth and regression, tissue and tumor sampling for ex vivo analysis, and various injection and small animal surgery techniques.
  • Experience in tumor immunology, biology of the tumor microenvironment, studying immuno-oncology drugs.
  • Working knowledge in regulatory requirements for preclinical animal experimentation.
  • Working knowledge in various experimental techniques, e.g., tissue culture, flow cytometry, leukocyte and lymphocyte subset, ligand binding assay, cell biology of intracellular signaling, molecular biology, and protein analytics, used for ex vivo assessment of antitumor drugs is a major plus.