Sr. Scientist I/II, Computational Chemist

Seattle, Washington
Mar 07, 2018
Required Education
Position Type
Full time

In this role, you’ll support the research project team with computational chemistry for drug discovery projects. You will help create intellectual property for small molecule inhibitors through the identification of critical interactions between our inhibitors and target enzymes. Additionally, you will oversee our drug discovery database management systems and evaluate our in-house and external screening libraries against our GPCR and MASP targets.

Good things are happening at Omeros!

Come join our Discovery Team!

Who is Omeros?

Omeros is a Seattle-based biopharmaceutical company committed to discovering, developing, and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, coagulopathies, and disorders of the central nervous system.

Part of its proprietary PharmacoSurgery® platform, the company's first drug product, OMIDRIA® (phenylephrine and ketorolac intraocular solution) 1%/0.3%, was broadly launched in the U.S. in April 2015. OMIDRIA is the first and only FDA-approved drug (1) for use during cataract surgery or intraocular lens (IOL) replacement to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce postoperative ocular pain and (2) that contains an NSAID for intraocular use. In the European Union, the European Commission has approved OMIDRIA for use in cataract surgery and lens replacement procedures to maintain mydriasis (pupil dilation), prevent miosis (pupil constriction), and to reduce postoperative eye pain.

Omeros has clinical-stage development programs focused on: complement-associated thrombotic microangiopathies; complement-mediated glomerulonephropathies; Huntington's disease and cognitive impairment; and addictive and compulsive disorders. In addition, Omeros has a proprietary G protein-coupled receptor, or GPCR, platform, which is making available an unprecedented number of new GPCR drug targets and corresponding compounds to the pharmaceutical industry for drug development, and a platform used to generate antibodies.

What are your job responsibilities?

  • Contributing to small molecule lead discovery programs and actively implementing cheminformatic tools
  • Overseeing drug discovery database management systems, including data mining and statistical evaluation
  • Guiding compound design on multiple projects, interfacing with medicinal chemistry, structural biology and assay groups
  • Compound property and diversity analysis of high throughput and focused screening libraries
  • Develop new approaches for designing relevant chemical features using scoring functions, statistics and machine learning
  • Working closely with medicinal chemistry and biology, develop tools to better understand structure activity relationships
  • Operating, maintaining and developing PC- and server-based computational software packages
  • Analyzing, preparing and presenting data
  • Ensuring safety standards are maintained
  • Managing and archiving data
  • Presenting scientific results effectively
  • Attending project meetings

What education and experience do you need?

You’ll need to have a minimum of a PhD, or equivalent, in Chemistry with relevant experience in small molecule cheminformatics, or a PhD in Cheminformatics with experience in medicinal chemistry. 1 - 5 years of related industry experience is required.

What skills and knowledge does our ideal candidate have?

As our ideal candidate, you’ll need the follow skills and knowledge:

  • Demonstrated proficiency in using MS Office applications
  • Demonstrated analytical and problem-solving skills
  • Detail orientation
  • A demonstrated ability to build and maintain positive relationships with management, peers, subordinates and others
  • Excellent interpersonal, verbal and written communication skills
  • Time management skills; ability to work effectively under pressure, handling multiple priorities simultaneously
  • Ability to work in a team oriented, highly motivated environment

If you have the skills, knowledge and experience we are looking for, we’d love to hear from you!

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to or contact Omeros, asking for Human Resources, at (206) 676-5000.