Senior Scientist, Modeling

Employer
AbbVie
Location
Lake County, Illinois, USA
Posted
Mar 07, 2018
Ref
1801724
Required Education
Bachelors Degree
Position Type
Full time
AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 25,000 people worldwide and markets medicines in more than 170 countries. Process Research and Development invents chemical processes and prepares active pharmaceutical ingredient (API) to enable clinical trials, toxicology studies and drug product development for Abbvie's pre-clinical and clinical drug pipeline. In addition to working with small molecules, Process R&D (PRD) also develops antibody drug conjugates (ADC). We create valuable intellectual property through composition of matter, chemical processes and technology resulting in a cost effective commercial manufacturing process. We develop the supply chain for APIs, prepare and defend CMC (Chemistry, Manufacturing and Control) regulatory content. PRD engineers/scientists in AbbVie's R&D work in multi-functional teams to develop scalable processes and supply API for safety testing, clinical trials and formulation development. The teams include Process Chemistry, Pilot Plant Operations, Analytical Chemistry and Solid State Chemistry. PRD engineers/scientists support API projects through all phases of development. Early in development, engineers concentrate on ensuring the process can be run safely, identifying and addressing major scale-up issues and developing the final (API) process step. Later in the development process, they optimize the API process and lead process campaigns run in the R&D Pilot Plant. In the final stage of development, they transfer the optimized process to manufacturing and support process validation.

Key Responsibilities Include:

The successful candidate at the least is expected to

· proactively seek opportunities to come up with innovative solutions to cater challenging business problems through creative application of modeling and simulation

· build and integrate mathematical models for a variety of chemical/biological API processes, process equipment and drug devices and simulates and validates models using appropriate technologies and experimental data

· provide deeper and robust understanding of properties/process/product performance correlations using appropriate modeling and simulation tools that otherwise is not amenable through simple experimentation

· harness power of mathematical modeling to come up with innovative designs of process, equipment and drug devices in a strongly collaborative environment involving chemists/ pharmacists/ biologists/ engineers

· carry out hands on experimentation

· exhibit a strong motivation to implement and advance various modeling technologies across AbbVie

· procure and deploy pertinent modeling technologies and computational hardware

· learn and venture into new areas of business interest

· play a strong team player in a cross functional collaborative environment thriving for world class excellence

· demonstrate excellent communication skills and specifically

o illustrate strong oral and written technical communications

o seamlessly present modeling solutions to multifunctional teams

o educate and train colleagues on various modeling tools and techniques

Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher
  • performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.
  • Level and compensation will be commensurate with experience.

Qualifications
Basic:
  • BS,MS, or Ph.D in chemical engineering or computational chemistry with a strong background of mathematical modeling, machine learning, molecular modeling, computational fluid dynamics (CFD) and chemical process modeling with
  • 10+(BS), 8+(MS), or 0+(Ph.D) years of experience
  • demonstrated experience in the model guided materials design, development and optimization of chemical processes as well as troubleshooting and improvements of established manufacturing processes using various kinds of modeling tools and techniques.
  • Experience in the area of machine learning with demonstrated ability to build and integrate mathematical and statistical models.
  • Well versed with Matlab and MS Excel based computational programming.
  • Experience with hands on experimentation is a plus
  • Experience in finite element analysis (FEA), discrete element modeling (DEM), molecular dynamics (MD) and the development of graphical user interfaces will be a plus.

Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled