Scientist - Tumor Biology

Tarrytown, NY, US
Mar 02, 2018
Required Education
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.SummaryThe Oncology and Angiogenesis group at Regeneron is currently seeking a highly motivated scientist candidate with PhD / postdoctoral experience in cancer biology and the tumor microenvironment. In this position, the candidate will have an opportunity to study the role of stromal components (fibroblasts, endothelial cells, extracellular matrix) in different tumor models including patient derived xenografts (PDXs) and clinical specimens.The qualified candidate will be responsible for conducting complex in vivo and ex vivo tumor studies to dissect the role of the tumor stroma. The scientist will help conduct experiments with in vivo tumor models, including PDX models, analyzing data and helping to integrate in vivo information with the goal of identifying targetable molecules/pathways. The qualified individual will have a strong background (PhD and/or postdoctoral experience) in one or more areas of tumor biology, tumor stroma, extracellular matrix and immuno-oncology with in vivo experience. Expertise with various tumor models (xenograft, syngeneic & GEMM models, monitoring tumor growth, iv, sc, ip, im injections, minor surgeries and necropsy) is required. Experience with in vivo imaging, immunohistochemistry, gene expression profiling including single cell transcriptomics, and flow cytometry are desired. Excellent communication and interpersonal skills are required as this candidate will be expected to work productively in a collaborative, cross-functional team environment. Attention to detail and timelines coupled with an aptitude for learning are also key elements of the position.Responsibilities• Independently plan and execute in vitro and in vivo tumor experiments• Understand, analyze, and interpret various forms of data, including molecular profiling data• Synthesize results across experiments and programs in PowerPoint presentations• Present results to senior scientists and management• Interrogate available PDX models on the role of the tumor stroma• Tissue processing, sectioning and histology/immunohistochemistry experience is a plus• Flow cytometry experience is a plus• Experience in in vivo imaging (bioluminescence and micro-ultrasound) is a plus• Experimental lab work (in the vivarium and well as the laboratory) will be ~ 60-70% of the job
PhD with 3+ years of experience
Must have Stromal experienceThis position will require the individual to pass a physical before beginning employment.This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.