Toxicologist Discovery & Investigative Fellow I

San Diego, California
Mar 01, 2018
Required Education
Position Type
Full time

Vertex Pharmaceuticals uses cutting edge science and technologies to transformative therapies for the treatment of the most serious diseases with unmet medical need.   Our culture enables individual empowerment where “We Wins” “Fearless Pursuit of Excellence” and “Innovation” are more than just corporate values; they are part of our everyday lives.
Pre-clinical Safety Assessment is a global function responsible for the design and execution of preclinical strategies for the safety assessment of transformative Vertex therapies at all stages of discovery and development.  The incumbent for this position will be located at our Research site in San Diego, CA and will be responsible for the early safety assessment supporting Vertex Discovery programs for cystic fibrosis and other serious diseases. This will include both small molecule and nucleic acid-based therapeutics.
Summary of Responsibilities: 

  • Advise, strategically plan, and manage San Diego discovery toxicology programs from target selection through clinical candidate selection.  The qualified candidate would also have the opportunity to support further toxicological evaluation through IND submission.
  • Serve as toxicology representative on project teams and act as primary point of contact for all toxicology efforts in support of Vertex San Diego drug discovery programs. Communicate critical project information to various bodies including project teams and Vertex leadership as required.
  • Establish a culture of ownership and deep scientific involvement and build strong cross-site collaborations between Pre-clinical Safety Assessment and discovery teams in San Diego.
  • As part of the Global Discovery and Investigative Toxicology Team assist in developing and implementing a multisite strategy for Discovery Toxicology within Vertex encompassing state of the art in silico, in vitro and in vivo technologies critical for selection and optimization of Vertex compounds for further development.
  • Collaborate on design and execution of investigative toxicology studies in support of development compounds.
  • Build strong scientific collaborations with external groups within both the academic and industrial sectors in support of above

Minimum Qualifications

  • Ph.D. in Toxicology, Pharmacology or a related field.
  • Five years or more experience in the Pharmaceutical Industry with proven abilities within the Discovery Toxicology/Investigative Toxicology arena for predictive safety assessments.
  • Proven ability to creatively seek resolutions to issues of predictive toxicology.
  • Highly organized and flexible problem solver with the ability to lead and adapt to new information and priorities.
  • Strong interpersonal skills with an ability to influence and develop long term relationships.
  • Working knowledge of drug discovery.

Preferred Qualifications

  • DABT Board certification preferred
  • Ability to navigate and be successful in a fast-paced, highly-matrixed work environment
  • A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society.
  • Company Information

    Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. 

    Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and offices around the world. For several consecutive years, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the Company, please visit 

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at