Sr. Research Associate I, BioAnalytical Sciences, (HPLC and Mass Spectrometry)
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.
Our Translational Sciences (TS) department is composed of four collaborative and inter-dependent teams: 1) BioAnalytical Sciences 2) Immunogenicity Assessment 3) Clinical Pharmacology and 4) BioMarker Discovery. Each team plays an integral role in drug development across BioMarin's innovative pipeline from discovery through clinical development and ongoing support for BioMarin's six marketed products. Our teams are empowered by to apply multiple therapeutic platforms to address unmet medical needs in rare disease including; small molecule drugs, protein therapeutics, oligonucleotides and gene therapy. BioMarin offers a unique opportunity to contribute broadly to novel therapeutics and rapidly translate the work to real impact on rare disease patients and families.
SUMMARY: Critical to the success of each new therapeutic, the BioAnalytical R&D group develops and validates novel assays to measure pharmacokinetics, immunogenicity and biomarkers. We are searching for a highly-motivated Senior Research Associate (SRA) to develop and validate assays that will impact non-clinical and clinical studies with innovative new technologies and methodologies. This position offers a unique career opportunity to master a variety of biological and analytical skills as well as the cutting-edge technologies including nano-LC and mass spectrometry. Specifically, we are looking for a SRA with 6 years of assay development experience, who has a track record for building and performing assays for proteins, small molecules, and/or oligonucleotides to answer biological questions using LCMS platforms. This SRA will report to a Scientist in BioAnalytical R&D, and will have the opportunity to contribute to a wide spectrum of drug development programs of a growing biotech company. The SRA will design and execute technically complex experiments, provide quantitative sample analysis and data interpretation, and contribute to technical reports (e.g. assay qualification and validation reports, SOPs). The SRA will carry out assay development, troubleshooting and validation. The SRA also evaluates analytical methods and technologies, identifies new areas requiring process improvement and adapts existing processes or develops new ones with direct input and supervision from a manager. They may contribute to scientific publications and regulatory submission as required. RESPONSIBILITIES:
Develop a variety of analytical methods to detect drug, metabolites and biomarkers in biological matrices. Techniques may include (but are not limited to) immunoprecipitation (IP), solid phase extraction (SPE), liquid-liquid extraction (LLE), mass spectrometry, HPLC, UPLC, and nanoLC.
Test non-clinical and clinical samples and deliver quantitative data in a timely manner.
Present results, conclusions, and implications to BioAnalytical R&D group.
Prepares SOPs and other documents such as assay qualification protocols, qualification reports, and data reports for testing results.
Develops new techniques/methodologies, or brings in new technology from the outside, to enhance the analytical capabilities of the group.
Share responsibility for lab management duties.
Participates and presents data as a member of bioanalytical teams, and shares responsibility for project milestones.
Participates in scientific meetings and produces original peer-reviewed publications
Other duties as assigned.
EXPERIENCE AND EDUCATION:
Bachelors degree with 6 - 10 years of relevant experience - OR - a Masters' degree with 4 years of relevant work experience
Required Skills: 6 - 10 years of hands-on experience in basic biochemistry (immunoprecipitation, small scale protein purification, HPLC). Fast learner. Excellent verbal and written communication skills. Ability to use computer effectively for data analysis. Desired Skills: 6 - 10 years of experience in quantitative analysis in biological matrices or mass spectrometry-based proteomics. Broad technical proficiency. Working experience with GxP.