Research Associate II/III, Process Chemistry

Bothell, Washington
Feb 27, 2018
Required Education
Bachelors Degree
Position Type
Full time

The successful candidate will be responsible for assisting in the development of novel synthetic routes and chemical processes for anti-cancer drugs and proprietary drug linkers used for antibody drug conjugates (ADCs). The ideal candidate should possess an in-depth knowledge of organic chemistry, reaction mechanisms, and familiarity with modern synthetic methods and analytical techniques.  Candidates will have demonstrated the ability to evaluate and optimize chemical processes through experimental data collection and interpretation.  An academic background in organic chemistry is required.


  • Conduct route scouting studies to establish novel synthetic routes for drug linkers and active pharmaceutical agents
  • Design and execute experiments to identify key and critical process parameters
  • Identify and collect key experimental data to attain a fundamental understanding of process performance and capabilities
  • Draft detailed protocols of chemical processes
  • Provide technical recommendations based upon in-depth analyses of experimental results and process performance data
  • Assist in the transfer of chemical processes to third party manufactures, and develop novel and creative solutions to processing issues
  • Identification and development of analytical and purification methods (HPLC, LC-MS, ISCO, preparative LC, etc.) for a variety of purposes including in-process analysis and quantitation, impurity identification, purity/impurity profile determination, and establishing material release criteria
  • Utilize analytical methods for process monitoring and collaborate with analytical chemists to identify structure, origin, and downstream fate of process impurities
  • Present results in the form of written reports and oral presentations


  • M.S. in chemistry with 0-5 years or B.S. with 4-8 years of industry experience in a process or medicinal chemistry research group
  • In-depth knowledge of modern synthetic methods and mechanistic organic chemistry
  • Experience in multi-step organic synthesis including reaction design, execution, and development of workup, isolation, and crystallization procedures
  • Experience in collecting key experimental data to define process parameters and ensure process robustness
  • Experience in applying spectroscopic methods (NMR, LC-MS, IR, etc) for structure determination
  • Experience in developing and utilizing various analytical chromatographic techniques (HPLC, GC) for quantitative data collection
  • Excellent written and oral communication skills; enthusiasm, integrity, self-motivation, and ability to interact within a multi-disciplinary team

Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status, or disability status.