Sr. Scientist, Research Biology (DMPK / LC-MS/MS)

San Francisco, CA (Mission Bay)
Feb 21, 2018
Biotech Bay
Required Education
Position Type
Full time

The successful candidate is an experienced Bioanalytical Scientist with a strong background in LC-MS/MS. The candidate will be responsible to developing quantitative LC-MS/MS methods to support Nektar’s drug discovery programs.


The candidate will develop stage appropriate methods for in vitro/in vivo ADME and PK. Will liaise with the on-site and Nektar India Bioanalytical groups to facilitate methods transfer for GXP methods development. The candidate will be responsible for operating and maintaining the LC-MS/MS equipment. He/she will be a mentor/trainer for junior staff. The successful candidate must have a track record of performing in vitro DMPK experiments including but not limited to hepatocyte stability, microsomal stability, plasma/blood stability, plasma and protein binding according to defined protocols under general guidance. The candidate is expected to establish new assays as needed to advance projects. He/she will perform metabolite identification using API5500 Qtrap or Orbitrap mass spectrometer or equivalent in biological matrices from non-clinical/clinical studies. The candidate will analyze, interpret, compile, and summarize data and present conclusions to project teams and senior management. The candidate is expected to keep accurate record of experiments. He/she will write technical protocols and reports for INDs and/or NDAs. He/she is required to maintain compliance to company Environmental Health and Safety policies, procedures and practices.


A PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 5 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Must be an expert in scientific principles and concepts in LC-MS/MS, bioanalysis, and drug metabolism. Must be able to demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought. Must possess good oral & written communication skills. Must be able to demonstrate sound scientific judgment. Must be able to demonstrate problem-solving capabilities. Strong organizational skills are required. Good computer skills are required. Experience with metabolite identification software, such as MetabolitePiolt™ and LightSight® is a plus. Working knowledge of MS word, Excel, Power point is a plus. Experience working in an FDA regulated environment as they apply to laboratory practices, hands-on experiences in conducting ADME work for IND submission and study report writing are highly desired. Must be willing to work as part of a team. Must be able to demonstrate good interpersonal skills.

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