Postdoc - Postdoctoral Fellow - Targeting Immunoregulatory Signals in Antigen presenting Cells and

Employer
AbbVie
Location
Worcester, Massachusetts, USA
Posted
Feb 20, 2018
Ref
1708337
Discipline
Science/R&D, Immunology
Required Education
Doctorate/PHD/MD
Position Type
Full time

IBD is a chronic autoimmune disease of the gut affecting millions of people worldwide. Several studies over the past decade using mouse model of colitis and human IBD samples have established the central role for antigen presenting cells and CD4+ T cells in induction and regulation of intestinal inflammation. Under normal physiological conditions APCs continuously monitor GI tract and maintain mucosal homeostasis through strong induction of regulatory T cell responses. However, in IBD patients, the intestinal dysbiosis and break in intestinal epithelial barrier lead to activation of gut resident APCs and T cells that initiate IBD pathology. Therefore targeting regulatory signaling in APCs and T cells could help restore the immune homeostasis at site of inflammation and offer a novel therapeutic replacement for currently available broad spectrum immunosuppressive drugs.

The current project interrogates the effect of targeting immune regulatory signals in APCs and T cells using 2 following approaches and its impact on immune tolerance:

· Regulating -catenin signaling in CD4 T cells to restore immune tolerance during IBD: Recently published studies and our in-house data indicate that activation of Wnt/β-catenin signaling in DCs and terminally differentiated CD4+ T cells induces strong immunoregulatory phenotype. Project hypothesizes that the activation of β-catenin pathway during naïve CD4+ T cell differentiation promote Treg and induce strong immune tolerance and suppress auto-immune pathologies.

· Fine tuning the immune inhibitory receptor signal on antigen presenting cells to induce immune tolerance during inflammation: Immune inhibitory receptors are a class of surface receptors that keeps the unwanted immune responses under check to avoid autoimmunity, while maintaining full potential to combat infection and cancer. The project proposes to understand the signaling dynamics of these receptors in APC and modulate the signals to fine-tune the APCs to induce tolerance.

Qualifications:

Basic:

  • Successful completion and defense of a PhD/Immunology. Minimum graduate school GPA 3.0; 3.5 preferred. Graduate of accredited and nationally ranked university.
  • Research background in mucosal immune tolerance
  • Record of publication in a prestigious journal(s).
  • Excellent problem-solving skills including critical and analytical thinking.
  • Excellent communication, leadership, and project management skills. Demonstrated scientific writing skills and strong verbal communication skills.
  • Demonstrated ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies.
  • Proven track record of teamwork, adaptability, innovation, initiative, and integrity. Global mindset to thrive in a diverse culture and environment.
  • Ability to multitask and work within timelines.

Preferred:

· Research background in mucosal immune tolerance

· Working experience with in vivo mouse colitis models

· Working knowledge of antigen presenting cells and T cell based in vitro and in vivo differentiation and cell proliferation assays,

· Experience with multi-color flow cytometry and training in molecular biology techniques such as Western blot, immunoprecipitation, ELISA.

· Hands on training in signal transduction assays and up-to-date knowledge of current literature in cell signaling pathway.

Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Equal Opportunity Employer Minorities/Women/Veterans/Disabled