Senior Scientist, Antibody Engineering

Worcester, Massachusetts, USA
Feb 20, 2018
Required Education
Bachelors Degree
Position Type
Full time

We are seeking an accomplished scientist who will make substantial contributions to the conception, execution and communication of antibody discovery strategies in a highly collaborative environment.

Key Responsibilities:

  • Develop and execute research strategies to enable the discovery and development of therapeutic antibodies and antibody drug conjugates for AbbVie's core therapeutics areas
  • Design and execute in vitro display technologies for lead antibody
  • Identify/ optimize and collaborate to generate stage-gate appropriate in vitro / cellular / in vivo data packages supporting PoC
  • Develop and implement research to gain a detailed mechanistic understanding of the molecular pharmacology of therapeutic molecules
  • Generate internal and external collaborations as necessary to further program goals
  • Drivie antibody/ADC discovery programs within a multidisciplinary research group in an exciting, fast-paced team environment

Position will be hired based on level of experience.

Basic Qualifications:

  • BS, MS, or PHD in immunology, cell biology, molecular biology, protein/antibody engineering or closely related fields with 10+ years (BS) 8+ years (MS) or 0+ years (PhD) of relevant experience.
  • Significant research experience as demonstrated by track record of publications and scientific accomplishments
  • Hands-on experience with in vitro antibody discovery display technologies (e.g., phage, yeast display)
  • Antibody/antibody fragment library design and construction
  • Strong molecular biology skills
  • Deep understanding of antibody structure and function
  • Experience in antibody engineering and optimization (e.g., humanization, Fc optimization)
  • Highly developed leadership and communication skills
  • Keen ability to engage internal and external scientific leaders in collaborative research
  • Excellent organization skills and the ability to manage multiple projects simultaneously
  • Work in a collaborative environment with functional and therapeutic areas
  • Adapt to rapid changes in project priorities and timelines

Preferred Qualifications:

  • Experience leading biologics discovery projects
  • Background in protein expression and purification
  • Experience with protein characterization (e.g., MS, SEC, etc.)

Key AbbVie Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance
  • Learns fast, grasps the “essence” and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Equal Opportunity Employer Minorities/Women/Veterans/Disabled