Senior Scientist (NCI)

Frederick, Maryland
Feb 02, 2018
Required Education
Position Type
Full time



The Clinical Services Program's primary mission is to perform sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease or other diseases associated with immunologic dysfunction, as well as to monitor viral load in patients with HIV.


  • The Senior Scientist will direct the Clinical Support Laboratory, a laboratory group providing clinical trial support the National Cancer Institute Center for Cancer Research (CCR) that includes performing cell based assays including lymphocytes proliferation, ELISPOT testing, and cytotoxicity assays and will work with CCR investigators to identify additional assays that can be developed to evaluate relevant clinical markers under validated conditions. 
  • Laboratory activities also include regulated testing under the Clinical Laboratory Improvement Amendments (CLIA) and the successful applicant must meet regulatory agency requirements to be a technical supervisor under CLIA.
  • Will also provide scientific and laboratory management support to the closely associated Clinical Support Laboratory. 
  • That laboratory provides clinical and pre-clinical sample processing and cryopreservation support, ELISA and multiplex testing of biomarkers, and flow cytometry support.
  • In addition to dedicated support to CCR includes supervision of dedicated and core service projects to other NCI divisions or institutes. 
  • Will work with clinicians, nurses and regulatory staff to develop clinical trial monitoring strategies and resolve and document discrepancies.  Will provide CLIA testing supervision and report preparation. 
  • Will develop and implement standard operating procedures and provide staff training in high complexity biological testing. 
  • Will work with program management to develop cost estimates for customer work scopes. 
  • Will attend project meetings as needed.  Expected to present at scientific meeting and publish in peer-reviewed publications.
  • Work involves blood and blood products from cancer patients but may also involve work with samples from patients with HIV, or other infectious diseases requiring use of personal protective agreement with some work performed in a BSL-2 laboratory using BSL-3 lab practices.
  • The laboratory also provides some processing and testing support of blood and tissue samples obtained from non-human primates and rodents with all work performed under projects approved by the Institutional Biosafety Committee.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education).Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to educational requirements, a minimum of five (5) years post-graduate experience of competent, innovative research is required
  • Must be able to obtain and maintain a security clearance

    Candidates with these desired skills will be given preferential consideration:

    • Flow cytometry, nucleic acid isolation
  • Previous supervisory and/or management experience in a diverse work environment. 
  • Must have excellent verbal communication skills and be able to provide examples of written scientific communication.
  • Documented experience with bioassays to evaluate immunological function.
  • Experience with ELISPOT assays.
  • Experience with multiplex testing of biomarkers.