Enzyme Engineering

San Diego, California
Jan 23, 2018
Required Education
Bachelors Degree
Position Type
Full time

Enzyme Engineering

Apex Life Sciences is searching for an experienced candidate with experience in Enzyme Engineering to work for our Client in San Diego, CA.

Job Description

  • Plan and carry out experiments, analyze results, present findings, solve challenging technical problems
  • Design and optimize DNA sequencing methods using novel chemistries
  • Formulate and optimize critical reagents to be used with polymerases.
  • Carry out experimental work involving DNA/enzyme manipulation with an emphasis on quantitative analysis of results.
  • May use advanced techniques of fluorescence microscopy to push the boundaries of DNA sequencing performance (accuracy, read length, throughput)
  • Work closely with other members of the R&D team, with expertise in organic chemistry, surface chemistry, enzyme engineering, enzyme purification and application, physics, micro-fluidics, optics, signal processing and engineering.


  • PhD in Molecular Biology, BioChemistry, BioPhysics or related field
  • 6+ years R&D experience, post-PhD
  • Very strong quantitative analytical and experimental skills, and deep physical insights
  • Experience in Enzyme Kinetics, especially kinetics of DNA polymerases including measurement of all relevant kinetic parameters.
  • Apply quantitative methods to molecular biology methods including amplification.
  • Specific expertise in protein engineering by extensive mutagenesis.
  • Able to use existing crystallographic and sequence data to identify likely mutagenesis targets to improve DNA polymerase for novel nucleotides.
  • Demonstrated ability to come up with innovative ideas and develop them into commercial applications and intellectual property
  • Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace
  • Experiences preparing and running mutagenesis and screening pipelines.
  • Next-Gen sequencing experience a plus.