Scientist, Cancer Biology
Seattle Genetics is a biotechnology company focused on developing and commercializing innovative, empowered antibody-based therapies for the treatment of cancer. We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells.
We are seeking a highly talented and motivated scientist with a strong cancer biology and/or cell biology background to join the Cell Biology team. The successful candidate will lead independent efforts to advance the company's drug research pipeline.
- Apply leading edge in vitro and in vivo oncology methodologies to evaluate activity and mechanism(s) of antibody therapeutics, small molecule chemotypes, and ADCs
- Identification and validation of tumor antigen suitable for targeting specific cancer subtypes
- Generation and characterization of monoclonal antibodies and selection of small molecule chemotype payloads for novel ADC therapeutic development
- Improve the ADC development process by exploring novel avenues of cancer cell innate sensitivity and resistance to our small molecule drug payloads
- Present data at project team meetings and seminars to drive recommendations for drug discovery and/or development decisions
- Ph.D. in Cancer Biology, Cell Biology, Biochemistry, Immunology or related fields in cancer research. Ideal candidates will have 2+ years of biotechnology industry experience, which may include postdoctoral fellowships
- Demonstrated understanding of signal transduction pathways and oncogenic events involved in regulating cell growth and differentiation, malignant transformation, and drug resistance
- Experience conducting research into either small molecule or protein biologic drug mechanisms of action
- Working knowledge of flow cytometry and other assays to measure receptor-ligand interaction, biochemical methods to interrogate signaling pathways, as well as utilization of lentiviral and CRISPR/Cas9 gene editing methodologies
- Some experience in the design and interpretation of cell line xenograft and patient derived xenograft (PDX) oncology studies to measure in vivo antitumor activity of small molecule and/or antibody therapeutics is preferred
- Excellent skills in written and oral communication, organization and multitasking, and working in a collaborative and cross-functional research environment
- A strong scientific publication record
Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status, or disability status.