Investigator, Lead Discovery–Novartis Institute for Tropical Diseases

Emeryville, California
Oct 20, 2017
Required Education
Position Type
Full time

The Novartis Institute for Tropical Diseases (NITD), relocated to Emeryville, California, is dedicated to fighting parasitic infectious diseases of high medical need in a dynamic working environment. NITD is an independent Institute within the Novartis Institutes for Biomedical Research (NIBR), and as such has full access to NIBR know-how and resources including the chemists of the Global Discovery Chemistry group and the Infectious Diseases drug discovery teams (antiviral and antibacterial) co-located in Emeryville. NITD is renowned for applying cutting-edge technologies to the discovery of high quality clinical candidates for the treatment of neglected diseases. The Institute has a highly collaborative culture and has close links with academic centers of excellence and a broad range of non-governmental and philanthropic organizations around the globe (Wellcome Trust, Bill and Melinda Gates Foundation, Medicines for Malaria Venture and Drugs for Neglected Diseases Initiative).

About the position:
We are seeking a biologist with relevant expertise in the screening of small molecules and mechanistic characterization of novel chemical entities. The successful candidate will lead from the bench with design and implementation of biochemical and cellular assays that support the discovery and characterization of novel anti-parasitic drugs.

Specifically the candidate will:
• Design, develop, and implement biochemical and cell-based screening assays to support drug discovery
• Characterize the in vitro pharmacological properties of anti-parasitic small molecule inhibitors
• Interpret complex results and provide input to multidisciplinary project teams supporting discovery and early preclinical development of drug candidates
• Collaborate across disciplines to provide innovative approaches to discovery challenges
• Troubleshoot assays and instrumentation
• Ensure integrity, quality, and timely delivery of data
• Communicate research strategy and results internally and externally
• Recruit, develop and manage people talent

Minimum requirements

• Ph.D. in relevant discipline with 0-5+ years of experience
• Experience with small molecule assay development, lead discovery and lead optimization, in a pharmaceutical setting is preferred
• Demonstrated ability to critically evaluate and achieve assay robustness, reproducibility, and data quality
• Authored peer-reviewed publications
• Keen interest and demonstrated experience in anti-infective drug discovery
• Excellent written and verbal communication skills
• Innovative mindset and collaborative spirit
• Positive attitude and “can-do” mentality