Associate Scientist II, Antibody Discovery

Location
Foster City, California
Posted
Oct 19, 2017
Ref
1096088
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

We seek an experienced Associate Scientist with skills in antibody discovery and engineering to join the Biotherapeutics discovery group. The successful candidate will join a small but growing team responsible for developing biologic drug candidates based on engineered antibodies and other protein modalities. He/she will work in a highly collaborative environment to identify, characterize and optimize antibody or other protein-based molecules for research and clinical development. He/she will play a leading role in establishing new biotherapeutics discovery capabilities and support lead generation efforts for projects across different therapeutic areas.

Essential Duties and Job Functions:
Discovery and/or optimization of therapeutic antibodies via phage or other display technologies will be a core component to this role, so considerable expertise in this area will be essential. Additional responsibilities may include design and testing of antibody or therapeutic protein variants with enhanced activity or biophysical properties. Candidates with experience in flow cytometry and use of high throughput methods for lead candidate screening will be highly preferred.

Additional job requirements:
• Ability to design and execute on experiments independently.
• Proposes creative solutions for overcoming technical challenges
• Excellent ability to analyze/interpret data and recommend next steps.
• Good presentation skills and ability to communicate project goals and experimental findings to diverse audiences.
• Demonstrated ability to work successfully in a cross-functional and collaborative team environment.
• Maintain familiarity with scientific literature
• Be detail-oriented, organized and have excellent record keeping skills

Knowledge, Experience and Skills:
Applicants must have a BS with at least 12 years of related experience or an MS with at least 10 years of experience, preferably in industry. An ideal candidate will have direct experience in each of the following areas:
• Experience with one or more in vitro display systems (phage, yeast, mammalian) is strongly desired
• Strong background in molecular biology - cloning, vector design, mutagenesis
• Design and construction of antibody display libraries
• Experience with plate-based screening assays to identify and rank antibody leads (eg. ForteBio Octet, ELISA, HTRF etc)
• Experience with flow cytometry
• Understanding of antibody sequence, structure and activity relationship

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.