Principle Scientist, Global Investigative Toxicology

Groton, Connecticut
Oct 17, 2017
Science/R&D, Toxicology
Required Education
Position Type
Full time

We are seeking a highly motivated and accomplished laboratory scientist/investigator to join our nonclinical research team in Global Investigative Toxicology/Drug Safety Research and Development (DSRD). The primary responsibility of Global Investigative Toxicology is to design and carry out investigative studies to position toxicity findings for molecules in preclinical and clinical development. These efforts include hypothesis-driven mechanistic studies and the development of novel in vitro models. We are seeking a research scientist with expertise in the rapidly evolving areas of 2D and 3D in vitro co-cultures, organoids (such as CNS, liver, kidney or gut), stem cell-derived model systems (iPSC) and/or microphysiological (MPS) models (e.g., fluidics-enabled organ on a chip) to enable the development of more physiologically relevant in vitro assays to improve safety assessment of novel therapeutic molecules.

* Reports to a Director/ Senior Director of Global Investigative Toxicology
* Provides scientific expertise in the areas of cell culture, 2D and 3D co-cultures, organoid generation and characterization, development and utilization of iPSCs and MPS models
* Develops novel in vitro methods that can be used to address toxicity findings/screen subsequent molecules to eliminate toxicity
* Generates high quality laboratory-based investigative data to support portfolio progression and/or mechanistic understanding of toxicity findings
* Analyses, documents and reports laboratory data in accordance with company standards and procedures
* Effectively communicates experimental findings in both oral and written formats
* Functions collaboratively as part of a global multi-disciplinary team

* PhD degree in Pharmacology, Toxicology, Molecular Biology, Bioengineering, or a related field; Post-doctoral experience highly desirable
* Expertise in organ toxicity such as gut, liver, CNS and/or kidney
* Prior experience with tissue culture (in particular, primary cultures), iPSC- and MPS-based 3D in vitro models, complex microtissues and organoids
* A track record of publication and scientific presentations (e.g., abstracts, posters, podium presentations) related to 3D, iPSC- and MPS-based science.
* Knowledge of endpoint assays such as biochemical assays, PCR, western blotting, IHC, flow cytometry, basic high content imaging

Additional Details:

  • Eligible for Employee Referral Bonus
  • Pfizer US Exempt Grade 11

EEO & Employment Eligibility

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