Exelixis, Inc. Announces November 3 Webcast Of Its Third Quarter 2005 Financial Results Conference Call

SOUTH SAN FRANCISCO, Calif., Oct. 20 /PRNewswire-FirstCall/ -- Exelixis, Inc. will announce its third quarter 2005 financial results on Thursday, November 3, 2005, after the markets close.

The announcement will be followed by a live webcast at 2:00 p.m. PST/5:00 p.m. EST of a discussion by Exelixis management of third quarter 2005 financial results. The webcast may be accessed in the Events page under Investor Information on the Exelixis website at http://www.exelixis.com.

An archive of this webcast will be available until 9:00 p.m. PST/12:00 a.m. EST on November 10, 2005. Access numbers for this replay are: 1-877-660-6853 (domestic) and 1-201-612-7415 (international); Conference ID number is: 174068.

About Exelixis

Exelixis, Inc. is a biopharmaceutical company dedicated to the discovery and development of novel therapeutics that will potentially enhance the care and lives of patients with cancer and other serious diseases. The company is leveraging its fully integrated gene-to-drug platform to fuel the growth of its proprietary drug pipeline. Exelixis’ development pipeline covers cancer and metabolism and is comprised of the following compounds: XL119 (becatecarin), for which a multinational Phase III clinical trial in bile duct tumor is ongoing and which has been exclusively licensed to Helsinn Healthcare S.A. with rights to reacquire commercial rights for North America; XL784, which is being advanced as a treatment for renal disease and is currently in a Phase I clinical trial using a newly developed capsule formulation of the compound; XL647, XL999, XL880, XL820, XL844 and XL184, anticancer compounds currently in Phase I clinical trials; and multiple compounds in preclinical development for diseases including cancer and various metabolic and cardiovascular disorders. Exelixis has established broad corporate alliances with major pharmaceutical and biotechnology companies including GlaxoSmithKline (GSK) and Bristol-Myers Squibb Company. Pursuant to a product development and commercialization agreement between Exelixis and GSK, GSK has the option, after completion of Phase IIa clinical trials by Exelixis, to elect to develop a certain number of compounds in Exelixis’ product pipeline, which may include the cancer compounds identified in this press release (other than XL119 but including XL784), thus potentially triggering milestone payments and royalties from GSK and co-promotion rights by Exelixis. For more information, please visit the company’s web site at www.exelixis.com.

Exelixis, Inc.

CONTACT: Charles Butler, Associate Director, Corporate Communications ofExelixis, Inc., +1-650-837-7277, or cbutler@exelixis.com