Cancer Immunotherapy Market Size to Increase USD 280.11 BN by 2033

According to Vision Research Reports, the global cancer immunotherapy market size was estimated at USD 125.73 billion in 2023 and it is projected to increase USD 280.11 billion by 2033 with a CAGR of 8.34% from 2024 to 2033.

According to Vision Research Reports, the global cancer immunotherapy market size was estimated at USD 125.73 billion in 2023 and it is projected to increase USD 280.11 billion by 2033 with a CAGR of 8.34% from 2024 to 2033. Cancer immunotherapy represents a paradigm shift in cancer treatment, offering novel strategies to enhance the immune system’s ability to recognize and eliminate cancer cells. By leveraging the body’s natural defense mechanisms, immunotherapy holds the promise of targeted and durable responses with fewer side effects compared to conventional therapies.

Types of Cancer Immunotherapy

Checkpoint Inhibitors: Checkpoint inhibitors work by blocking inhibitory pathways that cancer cells exploit to evade immune detection. Drugs such as pembrolizumab and nivolumab have shown remarkable efficacy in various cancer types, including melanoma, lung cancer, and renal cell carcinoma.

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CAR-T Cell Therapy: Chimeric Antigen Receptor (CAR) T-cell therapy involves genetically modifying a patient’s T cells to recognize and destroy cancer cells. This personalized approach has demonstrated remarkable success in treating hematologic malignancies like leukemia and lymphoma.

Cancer Vaccines: Cancer vaccines aim to stimulate the immune system to recognize and target cancer-specific antigens. Prophylactic vaccines, such as the human papillomavirus (HPV) vaccine, can prevent certain cancers, while therapeutic vaccines like Sipuleucel-T boost immune responses against existing tumors.

Adoptive Cell Transfer: Adoptive cell transfer involves harvesting immune cells from patients, modifying them ex vivo to enhance their anti-cancer activity, and then reinfusing them back into the patient. Techniques like tumor-infiltrating lymphocyte (TIL) therapy and natural killer (NK) cell therapy hold promise in treating various malignancies.

Monoclonal Antibodies: Monoclonal antibodies are engineered proteins that target specific molecules on cancer cells, thereby facilitating immune-mediated destruction. Drugs like rituximab and trastuzumab have become cornerstone therapies in the management of certain cancers.

Key Pointers

  • North America dominated the market with the largest market share of 45% in 2023.
  • Asia Pacific region is poised to witness the fastest CAGR from 2024 to 2033.
  • By Distribution Channel, the hospital pharmacy segment held the largest revenue share in 2023.
  • By Distribution Channel, the online pharmacy segment is expected to expand at the highest CAGR from 2024 to 2033.
  • By Product, the monoclonal antibodies segment generated the maximum market share of 67% in 2023.
  • By Application, the lung cancer segment commanded the largest revenue share in 2023.
  • By End Use, the hospitals & clinics segment registered the maximum market share in 2023

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The Promise of Immunotherapy in Cancer Treatment

  • Effective Treatment Options: Cancer immunotherapy has revolutionized cancer treatment by offering new and effective options for patients with various types of cancer. Clinical trials have demonstrated its efficacy in treating melanoma, lung cancer, bladder cancer, and many other malignancies.
  • Reduced Side Effects: Unlike traditional cancer treatments, which often cause significant side effects due to their nonspecific nature, immunotherapy tends to have fewer adverse effects. By targeting cancer cells specifically, immunotherapy can spare healthy tissues and organs from damage, leading to a better quality of life for patients.
  • Long-Term Benefits: One of the most significant advantages of cancer immunotherapy is its potential for long-term remission. In some cases, patients treated with immunotherapy have experienced durable responses, with cancer remaining in check for years after treatment.

Some Challenges:

  • Limited Patient Response: Not everyone responds well to immunotherapy. A major hurdle is identifying which patients will benefit most.
  • Tumor Resistance: Cancers can develop mechanisms to evade immune attack, rendering immunotherapy ineffective.
  • Autoimmune Reactions: Immunotherapy can sometimes trigger overactive immune responses, harming healthy tissues.
  • Cost and Accessibility: These treatments can be expensive, limiting access for some patients.

Distribution Insights

In 2023, the hospital pharmacy sector emerged as the predominant force within the market. This dominance can be attributed to the growing need for immunotherapies in hospital environments, alongside an uptick in hospitalizations due to the escalating incidence of cancer. Specifically, the complexities surrounding cancer treatment and the higher prevalence of patients aged 65 and above have led to a notable increase in hospital admissions among cancer patients. As a result, the Hospital Pharmacy segment holds a significant market share, reflecting its substantial presence.

Meanwhile, the online pharmacy sector is positioned for notable expansion, expected to maintain a substantial compound annual growth rate (CAGR) over the forecast period. Several factors contribute to this projected growth, including the rising demand for internet-based pharmacy services. This surge is propelled by factors such as the broader accessibility of the internet, increased adoption of telemedicine practices, and widespread use of technology for healthcare purposes, all of which enhance convenience and time efficiency for consumers.

Distribution Insights

In 2023, the monoclonal antibodies segment emerged as the market leader, capturing the largest revenue share of 67%. The increased investment in Research and Development (R&D) of monoclonal antibodies, which includes bispecific antibodies, conjugated monoclonal antibodies, and naked antigen-binding antibodies, has created growth opportunities within the oncology therapeutics sector. Modern monoclonal antibodies are meticulously engineered to confer adaptive immunity, antibody-dependent cellular toxicity, and antigen specificity, making them a focal point of extensive research for their therapeutic potential against various cancer types.

Meanwhile, the segment for oncolytic viral therapies and cancer vaccines is poised for significant market growth in the forecast period. Despite facing obstacles such as the lack of immunogenicity and immunosuppressive effects within the tumor microenvironment, the development of cancer vaccines shows promise for addressing unmet medical needs. According to the American Association for Cancer Research in June 2023, the US Food and Drug Administration has approved only a limited number of therapeutic vaccines.

Application Insights

In 2023, the lung cancer segment dominated the market with the largest revenue share. This dominance is fueled by several key factors, including the increasing prevalence of lung malignancies, heightened awareness programs, greater adoption of immunotherapy, and a robust pipeline of investigational candidates. Furthermore, the segment’s growth is propelled by the continuous influx of product approvals and launches. For instance, in November 2023, the US Food and Drug Administration (FDA) granted marketing authorizations to Augtyro (Bristol, Inc.) for the treatment of locally refractory or metastatic Non-Small Cell Lung Cancer (NSCLC) with Repotrectinib.

On the other hand, the Breast Cancer segment is set to register a significant compound annual growth rate (CAGR) over the forecast period. This projection is driven by factors such as the high prevalence of the disease, ongoing research and development endeavors, and substantial investments by key industry players to introduce novel therapeutics for breast malignancies. Notably, in November 2023, AstraZeneca received FDA approval for their breast cancer drug capivasertib in combination with fulvestrant, further highlighting the segment’s growth prospects.

End Use Insights

In 2023, the hospitals & clinics segment secured the largest revenue share. This dominance can be attributed to several factors, including the increasing incidence of diseases, higher treatment rates, heightened awareness, improved diagnosis of malignancies, and the widespread availability of immunotherapies in numerous hospitals. The adoption of immunotherapies by hospitals for cancer treatment is particularly noteworthy. According to an article published by the National Cancer Institute in April 2023, 25% of patients in the United States passed away in a hospital setting, with 62% being hospitalized at least once during the last month of life for cancer treatments.

Meanwhile, the Cancer Research Centers segment is anticipated to witness a significant compound annual growth rate (CAGR) over the forecast period. This growth trajectory is propelled by increased research on cancer and supportive activities conducted by governmental or national organizations in the form of grant funding, aimed at stimulating demand. As reported by Becker’s Healthcare in November 2023, Texas Oncology recently unveiled its Amarillo Comprehensive Cancer Center, representing a substantial investment of USD 150 million. This state-of-the-art facility is poised to advance cancer care by offering comprehensive services in the Amarillo region, thereby bolstering the market.

Regional Insights

In 2023, North America solidified its dominance in the market, capturing a significant 45% share. This stronghold is propelled by several factors, including increasing patient awareness, a high burden of disease, proactive government initiatives, technological advancements, and enhancements in healthcare infrastructure. Moreover, the presence of key industry players in this region significantly contributes to market growth. As reported by Elsevier Ltd. in April 2023, the US National Cancer Institute published its anticipated national cancer plan, outlining a roadmap and a call to action for enhancing all aspects of cancer care, from prevention and detection to diagnosis, treatment, and recovery.

Meanwhile, the Asia Pacific region is poised to witness the fastest compound annual growth rate (CAGR) in the global market. This growth trajectory is fueled by factors such as the burgeoning elderly population, a substantial number of patients with targeted diseases, and improvements in healthcare infrastructure. Additionally, the expansion of this region is facilitated by the increasing legal acceptance of immunotherapeutics. For instance, as per the MJH Life Sciences article published in November 2023, China’s National Medical Products Administration approved durvalumab (Imfinzi) in combination with gemcitabine and cisplatin for frontline use in adult patients with locally advanced or metastatic biliary tract cancer, further underscoring the region’s growth potential.

Cancer Immunotherapy Market Key Companies

  • Pfizer Inc.
  • AstraZeneca
  • Merck & Co., Inc
  • F. Hoffmann-La Roche Ltd
  • Bristol-Myers Squibb Company
  • Novartis AG
  • Lilly
  • Johnson & Johnson Services, Inc
  • Immunocore, Ltd

Cancer Immunotherapy Market Segmentations:

By Product

  • Monoclonal Antibodies
  • Immunomodulators
  • Oncolytic Viral Therapies & Cancer Vaccines

By Application

  • Lung Cancer
  • Breast Cancer
  • Colorectal Cancer
  • Melanoma
  • Prostate Cancer
  • Head & Neck Cancer
  • Ovarian Cancer
  • Pancreatic Cancer
  • Others

By Distribution Channel

  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy

By End Use

  • Hospitals & Clinics
  • Cancer Research Centers
  • Others

By Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

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