University of Cincinnati Medical Center Preclinical Study Links Gene to Brain Aneurysm Formation

Published: Aug 07, 2007

CINCINNATI—University of Cincinnati (UC) neurovascular researchers have identified a gene that—when suppressed or completely absent—may predispose a person to brain aneurysms. Todd Abruzzo, MD, and his colleagues demonstrated that “knocking out” a gene known as endothelial nitric oxide synthase (NOS-3) in an animal model led to intracranial aneurysm formation in 33 percent of study subjects.

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