Sinusitis Treatment Market: Improved Intra-nasal Drug Delivery Helps to Improve Patient Quality of Life

Sinusitis Treatment Market: Introduction

According to the report, the global sinusitis treatment market was valued at US$ 2.9 Bn in 2020 and is projected to expand at a CAGR of ~4% from 2021 to 2031. Sinuses are a connected system of air-filled cavities located in the skull. Sinusitis is an inflammation of the sinus lining caused by bacteria, virus, fungi, or microbes. Bacterial sinusitis is less common than viral sinusitis and requires antibiotics, while viral sinusitis is most common and does not require antibiotics. Fungal sinusitis is also known as allergic fungal sinusitis, and caused by the aspergillosis fungi. Possible symptoms of sinus infections are nasal obstruction, discolored nasal discharge, and facial pain that lasts for seven days or more. Facial pain is a common symptom in sinusitis. A patient could feel pain around the eye, forehead, nose, and root of teeth.

The three primary types of sinusitis are acute sinusitis, sub-acute sinusitis, and chronic sinusitis. Acute sinusitis is also known as acute bacterial rhinosinusitis, and it lasts less than 30 days, while chronic sinusitis lasts more than three months. Sinusitis infection can be diagnosed through physical examination of color and characteristics of nasal mucosa, presence of polyps, and structure of nasal septum. Imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound can also be used for the diagnosis of sinus infections.

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Increase in Mucosal Inflammation Leads to Sinusitis

The increase in mucosal inflammation leads to sinusitis. The mucosal inflammatory pathways become activated by allergens, microbial stimuli, or poorly understood exogenous or endogenous stimuli, which causes sinusitis. Certain deficiencies in local innate immunity are responsible for the increased sinus mucosal bacterial colonization/infection, including deficient local production of antimicrobial lactoferrin and deficient functioning of the bitter taste receptor TAS2R38. Conversely, certain innate factors, such as IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation. The precise physiologic role of these factors in innate or adaptive immunity is unclear; however, IL-33 could function as an alarm triggered by damage-associated molecular patterns. The cytokines IL-25 and TSLP, similarly promote proinflammatory tissue responses. These factors are anticipated to propel the global sinusitis treatment market.

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Antihistamines to Lead Sinusitis Treatment Market

In terms of treatment, the global sinusitis treatment market has been classified into analgesics, antihistamines, corticosteroids, antibiotics, sulphonamides, quinolones, and surgery. Antibiotics have been split into cephalosporin, penicillin, and macrolide. The surgery segment has been bifurcated into endoscopy and balloon sinusplasty. The antihistamines segment accounted for 32% share of the global market in 2020. The segment is anticipated to expand at a CAGR of 3.85% from 2021 to 2031. Antihistamines are over-the-counter medication used to relieve cold, sinus, and allergy symptoms. Hence, increase in usage of these drugs boosts the growth of the segment.

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Rise in Acute Sinusitis

Based on disease type, the global sinusitis treatment market has been categorized into acute sinusitis, sub-acute sinusitis, and chronic sinusitis. The acute sinusitis segment accounted for 35% share of the market in 2020. The segment is expected to expand at a CAGR of 4.03% from 2021 to 2031. Acute sinusitis is generally caused by common cold. Signs and symptoms could include nasal obstruction and congestion, which may block sinuses in patients and prevent drainage of mucus. Hence, rise in cases of common cold & flu increases the incidence of acute sinusitis. This, in turn, propels the global sinusitis treatment market.

Oral to be Highly Lucrative Route of Administration

In terms of route of administration, the global sinusitis treatment market has been segregated into topical, nasal, oral, and injectable. The oral segment accounted for 60% share of the global market in 2020. The segment is projected to expand at a CAGR of 3.72% from 2020 to 2031. The oral pathway has attracted the most attention due to unique advantages, including sustained and controllable delivery, feasibility for solid formulations, ease of administration, patient compliance, and an intensified immune response in the case of vaccines.

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Retail Pharmacies to be Major Distribution Channel

Based on distribution channel, the global sinusitis treatment market has been divided into online pharmacies, retail pharmacies, and hospital pharmacies. The retail pharmacies segment held 44% share of the market in 2020. The segment is likely to gain market share marginally to reach 44.70% by 2031, as drugs are easily available and various brands are offered at reasonable prices at retail pharmacies.

Asia Pacific to Lead Sinusitis Treatment Market

In terms of region, the global sinusitis treatment market has been segmented into North America, Europe, Latin America, Asia Pacific, and Middle East & Africa. North America is projected to account for a significant share of the global market because of higher prevalence of sinusitis. According to the Centers for Disease Control and Prevention (CDC), nearly 26.9 million people were diagnosed with sinusitis in the U.S. in 2019. Europe is anticipated to be a key market for sinusitis treatment due to rise in invasive bacterial diseases and innovation in diagnosis of bacterial infections. The sinusitis treatment market in Asia Pacific is expected to grow at a rapid pace during the forecast period due to increase in bacterial and viral diseases. However, factors, such as lack of knowledge of diagnostic tests and awareness among people about sinusitis is likely to hamper the growth of the market in the region.

Competition Landscape

The global sinusitis treatment market is fragmented due to the presence of a large number of leading players. Key players operating in the global market include Sun Pharmaceutical Industries, Inc., Pfizer, Inc., Janssen Pharmaceuticals, Inc. (Johnson & Johnson), Fresenius Kabi USA, LLC, Dr. Reddy's Laboratories, Inc., Novartis AG, Teva Pharmaceutical Industries Ltd., Sanofi, Abbott Laboratories, Bayer AG, Eli Lilly and Company, Bristol-Myers Squibb, Merck & Co, Inc., AstraZeneca plc, Amneal Pharmaceuticals LLC, GlaxoSmithKline plc., Aurobindo Pharma, Hikma Pharmaceuticals plc, Wockhardt, and Mylan N.V.

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