Researchers Discover New Gene In Colon Cancer: A Naturally Occurring COX-2 Inhibitor

Published: Dec 22, 2004

Cancer researchers at the Case Western Reserve University (Case) School of Medicine, University Hospitals of Cleveland (UHC) and the Howard Hughes Medical Institute have found a "Celebrex-like" gene that suppresses the growth of colon cancer. The researchers discovered that the gene, called 15-PGDH, is found in normal cells and is virtually undetectable in colon cancer cells. When the researchers restored the gene in tumor cells and injected them into immune-deficient mice, the mice showed little or no tumor development. The study appears in the Dec. 14 issue of the Proceedings of the National Academy of Sciences.

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