Wilex AG: Subsidiary Heidelberg Pharma To Present The Proprietary ATAC Technology Platform At The Annual World ADC Summit

Published: Sep 20, 2017

- Heidelberg Pharma shortlisted for World ADC Award

Munich, Germany, 20 September 2017 - WILEX AG (ISIN DE000A11QVV0 / WL6 / FSE) today announced that its subsidiary, Heidelberg Pharma Research GmbH, Ladenburg, Germany, will present at the 8th Annual World ADC Summit taking place on 20-22 September in San Diego, CA, USA.

This annual summit is expected to draw record attendance from over 650 companies including large and small pharma, biotech, academia as well as CROs, CMOs and industry suppliers that cover every element of Antibody Drug Conjugate (ADC) development. The World ADC Summit organizes cutting-edge science and transformative insights. Further information can be found at: http://worldadc-usa.com.

Details of the Heidelberg Pharma presentation

Antibody Targeted Amanitin Conjugates (ATACs): Expanding the ADC Landscape with a New Payload Targeting RNA Polymerase II
Presenter: Professor Andreas Pahl (Chief Scientific Officer)
Date: Thursday, 21 September 2017, 5:30 PM (CDT)
Venue: Sheraton San Diego Hotel & Marina

Heidelberg Pharma will discuss how Antibody Targeted Amanitin Conjugates (ATACs) represent a new class of ADCs using the payload Amanitin, which inhibits RNA polymerase II, a novel mode of action in oncology therapy. The presentation will include improvements in the technology and an update of the HDP-101 development, the first Amanitin loaded ADC directed against B-cell maturation antigens (BCMA) and scheduled to enter Phase I trials in Multiple Myeloma by the end of 2018.

Additionally, Heidelberg Pharma has been nominated a finalist for the 4th Annual World ADC Awards in the category "Best New Drug Developer". The Award's ceremony takes place on 21 September 2017 in the Bel Aire Ballroom of the Sheraton San Diego Marina at 7:15 PM (CDT).

About Heidelberg Pharma's proprietary ATAC technology
Antibody-drug conjugates (ADCs) combine the high affinity and specificity of antibodies with the potency of cytotoxic small molecules for the treatment of cancer. Antibody Targeted Amanitin Conjugates (ATACs) are ADCs whose active ingredient is made up of amatoxin molecules. Amatoxins are small bicyclic peptides naturally occurring in the death cap mushroom. They inhibit mRNA transcription by binding to RNA polymerase II, a mechanism that is crucial for the survival of eukaryotic cells. In preclinical testing, ATACs have been shown to be highly efficacious, overcoming frequently encountered resistance mechanisms and combating even quiescent tumor cells.

About WILEX and Heidelberg Pharma
WILEX AG is a biopharmaceutical company based in Munich, Germany, that serves as a parent and holding company. The Company's research and development work is conducted by its subsidiary Heidelberg Pharma Research GmbH based in Ladenburg. Heidelberg Pharma is the first company to develop the toxin Amanitin for use in cancer therapies using its proprietary Antibody Targeted Amanitin Conjugate (ATAC) technology and to advance the biological mode of action of the toxin as a novel therapeutic principle. This proprietary technology platform is being applied to develop the company's own therapeutic ATACs as well as in third-party collaborations to create a variety of ATAC candidates. The proprietary lead candidate is a BCMA ATAC for multiple myeloma. WILEX's clinical assets MESUPRON(R) and REDECTANE(R) have been partnered, while RENCAREX(R) is available for out-licensing and further development. WILEX is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol WL6. More information is available at http://www.wilex.com.

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