vTv Therapeutics To Present Two Posters At The 2017 Alzheimer's Association International Conference
HIGH POINT, N.C.--(BUSINESS WIRE)--vTv Therapeutics Inc. (vTv) (Nasdaq: VTVT) today announced that data on the company’s phase 3 Alzheimer’s candidate, azeliragon, an oral antagonist of the Receptor for Advanced Glycation Endproducts (RAGE), will be presented at the 2017 Alzheimer's Association International Conference (AAIC) held in London, England, July 16 – 20, 2017.
Details of the poster presentations are listed below:
Poster Title: “Assessment of Azeliragon QTc Liability through
Integrated, Model-Based Concentration QTc Analysis”
Poster Number: P1-066
Category: Therapeutics: Clinical
Date and Time: Sunday, July 16, 2017, 9:30 am – 4:15 pm GMT
Poster Title: “Effect of Food on the Pharmacokinetics of
Azeliragon in Healthy Adult Subjects”
Poster Number: P2-025
Category: Therapeutics: Clinical
Date and Time: Monday, July 17, 2017, 9:30 am – 4:15 pm GMT
Azeliragon, also known as TTP488, is a novel orally active small-molecule antagonist of RAGE. A broad range of human pathologic and experimental biologic investigation suggests that RAGE activation contributes to the pathogenesis of Alzheimer’s disease. Sustained Amyloid-ß interactions with RAGE at the blood-brain barrier (BBB) and in neuronal and microglial cells, play potentially major roles in amyloid plaque formation, neuroinflammation and chronic neural dysfunction – all hallmarks of Alzheimer’s disease.
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer’s disease and Type 2 diabetes as well as treatment of inflammatory disorders and the prevention of muscle weakness.
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