VenatoRx Pharmaceuticals to Present in vitro and in vivo Data for cefepime/VNRX-5133 at ECCMID 2018
Session #OE112 | Beta-lactamase inhibitors: from bench to bedside
April 22, 2018
Location: ePoster Arena 3
Oral Session #O0600. Time 16:00 – 16:05 CET – Efficacy of cefepime / VNRX-5133, a novel beta-lactamase inhibitor combination, against cephalosporin-resistant, ESBL-producing K. pneumoniae in a murine lung-infection model. W. Weiss, M. Pulse, P. Nguyen, D. Valtierra, K. Peterson, K. Carter, D. Pevear, C. Burns and L. Xerri.
Oral Session #O0603. Time 16:18 – 16:23 CET – Structural basis for serine- and metallo-beta-lactamase inhibition by VNRX-5133, a new beta-lactamase inhibitor (BLI) in clinical development. J.D. Docquier, F. De Luca, M. Benvenuti, C. Pozzi, D. Daigle, D. Pevear, C. Burns and S. Mangani.
Oral Session #O0606. Time 16:36 – 16:41 CET – Kinetic mechanism and parameters of inhibition of serine KPC-2, CTX-M15, p99 AmpC and metallo VIM-2 by the broad-spectrum beta-lactamase inhibitor VNRX-5133. D. Daigle, C. Burns and D. Pevear.
2-Hour Oral Sessions with Mini-Review
Session #OS108 | Drug combinations: pre-clinical evidence
April 22, 2018
Location: Hall L
Oral Presentation #O0575. Time 16:34 – 16:44 CET – Pharmacodynamics of the novel broad-spectrum beta-lactamase inhibitor VNRX-5133 in combination with cefepime in neutropenic female CD-1 mice with experimental pneumonia. P-C. Georgiou, M. Siopi, M. Tsala, C. Lagarde, W. Kloezen, R. Donnelly, J. Mouton and J. Meletiadis.
Paper Poster Session #76 (PS076)
VNRX-5133 plus cefepime: in vitro and in vivo data
April 23, 2018
12:30pm – 13:30pm CET
Location: Paper Poster Arena
Paper poster #P1536 – Potentiation of cefepime by the boronate VNRX-5133 versus gram-negative bacteria with known beta-lactamases. S. Mushtaq, A. Vickers, N. Woodford and D. Livermore.
Paper poster #P1537 – Pharmacokinetics-pharmacodynamics (PK-PD) of VNRX-5133, a broad-spectrum novel beta-lactamase inhibitor (BS-BLI), in combination with cefepime in a one-compartment in vitro infection model. B.D. VanScoy, J. McCauley, E.A. Lakota, H. Conde, S.M. Bhavnani, T. Henkel, L. Xerri, D. Pevear and P.G. Ambrose.
Paper poster #P1538 – Efficacy of cefepime / VNRX-5133, a novel broad-spectrum beta-lactamase inhibitor, in a murine bacteremia infection model with carbapenem-resistant Enterobacteriaceae (CREs). W. Weiss, M. Pulse, P. Nguyen, D. Valtierra, D. Pevear, C. Burns and L. Xerri.
Paper poster #P1539 – In vitro activity of cefepime alone and in combination with the broad-spectrum beta-lactamase inhibitor VNRX-5133 against ESBL and carbapenamases harbouring Enterobacteriaceae and Pseudomonas spp. R. Donnelly, W. Kloezen, M. Goldman, A.C. Van Mil, C. Lagarde, J. Meletiadisand and J. Mouton.
Paper poster #P1540 – VNRX-5133, a novel broad-spectrum beta-lactamase inhibitor, enhances the activity of cefepime against Enterobacteriaceae and P. aeruginosa isolates in a neutropenic mousethigh infection model. P-C. Georgiou, M. Siopi, M. Tsala, C. Lagarde, W. Kloezen, R. Donnelly, J. Meletiadis and J. Mouton.
Paper poster #P1541 – Susceptibility to cefepime / VNRX-5133 in 298 carbapenem-resistant Enterobacteriaceae producing serine- and metallo-beta-lactamases. J. Tyrrell, M. Wali, D. Daigle, A.F. Aboklaish, N. Kurepina, B. Kreiswirth, T.R. Walsh, D. Pevear and L. Xerri.
Paper poster #P1542 – In vitro activity of cefepime in combination with VNRX-5133 against meropenem and/or cefepime resistant clinical isolates of Pseudomonas aeruginosa. M. Estabrook, M. Hackel and D. Sahm.
Paper poster #P1543 – Antimicrobial activity of cefepime in combination with VNRX-5133 against a global collection of clinical isolates. M. Hackel and D. Sahm.
Paper poster #P1544 – In vitro activity of cefepime in combination with VNRX-5133 when tested against cephalosporin and carbapenem resistant beta-lactamase producing gram-negative isolates. K. Kazmierczak, M. Hackel and D. Sahm.
Paper poster #P1545 – The ability of broad-spectrum beta-lactamase inhibitor VNRX-5133 to restore bactericidal activity of cefepime in Enterobacteriaceae- and P. aeruginosa-expressing Ambler class A, B, C and D enzymes is demonstrated using time-kill kinetics. J. Hamrick, C. Chatwin, K. John, D. Pevear, C. Burns and L. Xerri.
About VenatoRx Pharmaceuticals, Inc.
Led by a world-class team of pharmaceutical veterans, VenatoRx is a private pharmaceutical company that is developing a new wave of antibiotic products to combat the increasing threat of carbapenem antibiotic resistance. VenatoRx’s lead product, VNRX-5133, is an injectable broad-spectrum beta-lactamase inhibitor (BLI) that directly inhibits all four Ambler classes of beta-lactamases. Early clinical studies of cefepime/VNRX-5133 have been completed and VenatoRx plans to start Phase 3 pivotal trials in mid-2018. In addition, VenatoRx has a broad pipeline of preclinical programs, including a broad-spectrum orally bioavailable BLI, and a novel class of Penicillin-Binding Protein (PBP) inhibitors that are impervious to beta-lactamase-driven resistance. For more information, please visit www.venatorx.com.
VenatoRx Pharmaceuticals, Inc.
Heather Hunter, 610-644-8935
Vice President, Communications
Source: VenatoRx Pharmaceuticals