Trillium Therapeutics Inc.'s Cancer Stem Cell Program to be Highlighted at American Society of Hematology
Published: Dec 02, 2010
Over expression of CD47 by leukemic stem cells is thought to deliver an inhibitory signal through the SIRP??receptor on macrophages, allowing the cancer cells to escape phagocytosis. Trillium is developing an antagonizing SIRP?Fc fusion protein that blocks this inhibitory signal, allowing host macrophages to attack the cancer.
“Trillium, through its CD200Fc and CD200 antibody programs, has a longstanding interest in immune regulation”, commented Trillium’s Vice President, R&D, Dr. Bob Uger. “The SIRP?Fc program allows us to extend this expertise into the field of leukemic stem cells, which have emerged as important targets in the search for more effective cancer treatments. We will continue to work closely with our academic colleagues to move this program forward and secure a third-party development partner.”
Trillium Therapeutics Inc. is a private biopharmaceutical company specializing in innovative therapies of immune-mediated conditions, such as autoimmune and inflammatory disorders, as well as cancer. Trillium has a broad portfolio of preclinical immunology programs, including two partnered programs that target the CD200 immunoregulatory axis; a CD200-specific monoclonal antibody for the treatment of cancer, and a CD200Fc fusion protein for the treatment of autoimmune and inflammatory diseases. In addition, the company is developing a SIRP? agonist that activates the CD47-SIRP? axis, suppressing macrophage activation. This agent is being developed to improve human hematopoietic stem cell engraftment, accelerate blood cell recovery post-transplantation, and enable engraftment with lower doses of stem cells (e.g. from cord blood). The company is also developing a SIRP?Fc fusion protein, a decoy receptor that blocks the CD47-SIRP? axis resulting in macrophage activation. This product is initially being developed as a treatment for acute myeloid leukemia. The company’s most advanced program, TTI-1612, is a cytoprotective recombinant growth factor that is being developed for the treatment of interstitial cystitis (IC) and the prevention of necrotizing enterocolitis (NEC). Trillium has a broad network of external academic and industry R&D collaborations, including several license agreements with major US biotechnology companies. The Company is supported by three premier Canadian venture capital investors: Vengrowth Private Equity Partners, Growthworks Capital and BDC Capital.
For more information, please contact:
Niclas Stiernholm, Ph.D. Chief Executive Officer Trillium Therapeutics Inc. 96 Skyway Avenue Toronto, Ontario, M9W 4Y9 Canada
Tel: (416) 595-0627 Fax: (416) 595-5835 firstname.lastname@example.org www.trilliumtherapeutics.com