T2 Biosystems Release: Study Published In Journal Of Antimicrobial Stewardship Shows Patients Diagnosed With T2Candida Panel Treated More Than Eight Times Faster
Published: Oct 03, 2017
LEXINGTON, Mass., Oct. 03, 2017 (GLOBE NEWSWIRE) -- T2 Biosystems, Inc. (NASDAQ:TTOO), an emerging leader in the development of innovative diagnostic products to improve patient health, today announced that Henry Ford Health System published the clinical impact of the T2Candida Panel in The Journal of Antimicrobial Stewardship. The study, titled “T2 Magnetic Resonance Assay Improves Timely Management of Candidemia,” compared the management of candidemic patients before and after the implementation of the T2Candida Panel and was designed to evaluate time to appropriate therapy. Patients tested with the T2 Magnetic Resonance (T2MR) platform were treated in a median of 5 hours, a more than 8-fold reduction as compared to that based on blood culture, which delayed appropriate therapy by a median of 44 hours. This speed advantage demonstrates that the T2MR platform is a valuable clinical tool to aid antifungal stewardship’s goal to deliver timely antifungal therapy for infected patients.
“This technology has shown it can expedite the detection of candidemia,” said Henry Ford study co-author Rachel Kenney, PharmD. “As a result, patients receive more prompt and appropriate antifungal therapy.”
In addition to speed, the use of the T2MR platform provided increased certainty to the identification of Candida infections. Consistent with the performance of blood culture and T2MR published in other studies, the Candida species was definitively identified in 93% of patients after implementation of T2MR and in only 57% of patients prior to implementation of T2MR. Prior to implementation of the T2Candida Panel, the only diagnostic tests used at Henry Ford were blood culture and beta-D-glucan (BDG).
“In our inaugural publication, we are excited to highlight innovative work done by antimicrobial stewardship clinicians to provide optimal care to their patients and be better stewards of antimicrobials,” said Eric Wenzler, PharmD, editor of the Journal of Antimicrobial Stewardship. “Henry Ford’s use of the T2Candida assay to significantly reduce time to appropriate antifungal therapy is an important advance in rapid diagnostics, patient care, and antifungal stewardship.”
The authors also identified an additional clinically relevant improvement in patient outcomes after the implementation of T2MR: a significant reduction of Candida ocular involvement from 30% to 12% was observed. The authors point out this could be associated with improved sensitivity of T2MR or due to improved timeliness of patient management by T2MR.
Although the study was not adequately powered to evaluate reduction in patient mortality rates, the authors note that appropriately treating patients within 24 hours of the onset of disease is proven to reduce mortality rates from 41% to below 16%. T2MR is the only diagnostic method presented in this study with the speed and accuracy necessary to enable therapeutic decisions that achieve this reduction in mortality.
“I expected that T2MR platform’s direct-from-whole-blood technology would be the biggest breakthrough in candidemia management in decades and these clinical data demonstrate the promise of culture independent diagnostics,” said Michael A. Pfaller, M.D., Emeritus Professor, University of Iowa and Clinical Advisor, T2 Biosystems. “The T2MR platform is improving patient care, antimicrobial stewardship, and hospital finances today - and the positive impact for hospitals should only grow as new tests become commercially available.”
The Journal of Antimicrobial Stewardship paper was published online at: http://www.jantimicrobialstewardship.org/issues/.
About the sepsis-causing pathogen Candida
Candida is one of the deadliest sepsis-causing pathogens with a startling mortality rate of approximately 40% among patients receiving current standard of care. It is one of the leading hospital-acquired bloodstream infections in the United States and half of Candida infections are misdiagnosed as being negative by blood culture. The patient and economic impacts of Candida are tremendous: patients average 40 days in the hospital at a cost of $130,000 each.
About T2 Biosystems
T2 Biosystems, an emerging leader in the field of in vitro diagnostics, is dedicated to saving lives and reducing the cost of healthcare by empowering clinicians to effectively treat patients faster than ever before. T2 Biosystems is focused on addressing critical unmet needs in healthcare starting with sepsis, one of the deadliest and most expensive conditions in hospitals today. The T2Sepsis SolutionTM is a unique approach that combines the standard of care for the management of sepsis patients with T2 Biosystems’ products, including the T2Dx® Instrument and T2Candida® Panel, and the T2Bacteria® Panel, which is commercially available in Europe and other countries that accept the CE Mark and available for research use only in the U.S. Powered by the proprietary T2 Magnetic Resonance technology, or T2MR®, the T2Sepsis Solution is proven to deliver better patient care and greater cost savings. Hospital customer experience has demonstrated faster time to effective treatment, shortened ICU and hospital lengths of stay, reduced use of unnecessary antifungals, and millions of dollars in savings. T2 Biosystems has an active pipeline of future sepsis products including additional species and antibiotic resistance, as well as tests for Lyme disease and hemostasis. For more information, please visit www.t2biosystems.com.
About the Journal of Antimicrobial Stewardship
The Journal of Antimicrobial Stewardship (JAMS) is the only exclusive journal devoted to the advancement of antimicrobial stewardship. The open-access journal publishes quarterly peer-reviewed articles on a variety of topics that pertain to antimicrobial stewardship including clinical microbiology, rapid diagnostic tests, pharmacoeconomics, disease state-based stewardship interventions and the evaluation of current and novel therapies that promote optimal infectious diseases practices in a variety of settings and institutions. JAMS publishes high-quality original research articles, review articles, editorial commentaries, and challenging patient scenarios. The aim of the Journal of Antimicrobial Stewardship is to provide timely, informative and innovative research articles on topics related to antimicrobial stewardship and infectious diseases pharmacotherapy. The goal of the Journal is to catalyze the change required to improve patient outcomes through the promotion of optimal antimicrobial stewardship practices. For more information about the Journal, please visit jantimicrobialstewardship.org or follow @JAMS_journal on Twitter. To register as an author and/or reviewer, visit the JAMS editorial manager at ojs.jantimicrobialstewardship.org. For any inquires, contact the Journal at firstname.lastname@example.org.
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Darlene Deptula-Hicks, T2 Biosystems
SVP & Chief Financial Officer
Amy Phillips, Feinstein Kean Healthcare
Chris Brinzey, Westwicke Partners