Sensei Biotherapeutics Reports New Data from Phase 1 Clinical Trial of SNS-301
- SNS-301 was well tolerated with a favorable safety profile across all dose levels in the Phase 1 study.
- No dose-limiting toxicities were observed at the three dose levels evaluated in the trial.
- All patients in the study experienced dose-dependent, ASPH-specific humoral and cellular immune responses, including ASPH-specific B-cell and T-cell responses.
- 75% (6/8) of evaluable patients achieved improvements in Prostate-Specific Antigen (PSA) doubling time and/or absolute PSA. Improvements in PSA doubling rate are an indicative measure of slowing disease progression.
“We are extremely encouraged by these clinical results from our Phase 1 study of SNS-301 which validate the potential of our proprietary SPIRIT drug development platform to generate novel immuno-oncology therapies,” said John Celebi, President and Chief Executive Officer of Sensei Biotherapeutics. “SNS-301 exemplifies Sensei Biotherapeutics’ ability to engineer promising therapeutic candidates designed to teach the immune system to recognize and attack cancer.”
This Phase 1 study of SNS-301 was initiated in January 2017 and enrollment of 12 patients was completed in February 2018. SNS-301 is the lead clinical candidate from Sensei Biotherapeutics’ proprietary SPIRIT drug development platform. Final results will be presented at a medical meeting in the second half of 2018 and initial enrollment in a Phase 2 efficacy trial is anticipated by the end of the year.
SNS-301 is a first-in-class immunotherapy candidate utilizing a bacteriophage viral vector that targets human aspartate β-hydroxylase (ASPH), a cell surface enzyme that is normally expressed during fetal development. Following fetal development, the protein is no longer expressed. Expression of ASPH is uniquely upregulated in more than 20 different types of cancer and is related to cancer cell growth, cell motility and invasiveness. ASPH expression levels are inversely correlated with disease prognosis.
Though enhanced antigen presentation and other engineered immunotherapeutic features, SNS-301 is designed to overcome self-tolerance and induce robust and durable humoral and cellular immune responses that are specific to ASPH. SNS-301 is delivered through intradermal injection and avoids time-consuming and uncomfortable infusions, greatly facilitating ease of use.
About Sensei Biotherapeutics
Sensei Biotherapeutics is a privately-held biopharmaceutical company developing immuno-oncology therapies that stimulate the immune system to ‘teach’ it to recognize cancer-specific antigens and attack cancer cells. The company’s patented and proprietary drug development platform, called SPIRIT, creates novel therapies that target neoantigens or altered self-antigens – which are antigens encoded by tumor-specific mutated genes – and are designed to overcome self- tolerance by eliciting a potent cellular and humoral immune response to eliminate cancer cells. Sensei’s precision medicine approach in immuno-oncology includes novel therapies along with companion diagnostics. The company’s lead drug candidate, SNS-301, is a first-in-class cancer immunotherapy candidate that targets a novel embryonic antigen and has successfully completed a Phase 1 clinical study. Sensei Biotherapeutics is located in Gaithersburg, MD. For more information, please visit www.senseibio.com.
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Kathryn Morris, 914-204-6412
Source: Sensei Biotherapeutics, Inc.