ProMIS Neurosciences to Present Data for Potential Best-in-Class Antibody Candidates for Parkinson's Disease at AD/PD 2019 Conference
TORONTO and CAMBRIDGE, MA, /PRNewswire/ - ProMis Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, will present data for new antibody candidates that show stringent selectivity for the toxic forms of alpha-synuclein, considered a root cause of Parkinson's disease. ProMIS Neurosciences' Chief Scientific Officer Dr. Neil Cashman will discuss the preclinical data at a podium presentation on March 31 as well as co-moderate the March 30 panel discussion on disease mechanisms in Alzheimer's disease and Parkinson's disease.
In the March 31 presentation, "Targeting of Pathogenic Aggregated Alpha-Synuclein: Refining Antibody Epitopes by Design," Dr. Cashman will present data showing how the ProMIS novel drug discovery and development platform created antibodies that:
"The ability to bind toxic forms and only the toxic forms of misfolded proteins in the brain has been a frustratingly elusive challenge in both Parkinson's and Alzheimer's drug development," explained Dr. Neil Cashman, a leading researcher in protein misfolding diseases. "This is largely because the toxic species of the affected proteins still share many similarities with the healthy forms of the protein, making them impossible to target with precision using traditional tools for developing antibodies. Using our unique discovery platform, we have been able to successfully address this problem. Our data show we can raise antibodies that bind the toxic species and only the toxic species of alpha-synuclein with exquisite precision while preserving the healthy forms of the protein."
Alpha-synuclein is an essential protein in the brain that can form toxic, misfolded clumps (aggregates), leading to progressive destruction of neurons in the brain. Two decades of research indicate that these toxic forms of alpha-synuclein are a root cause of Parkinson's disease and represent a major therapeutic target for drug development.
At the conference, Dr. Neil Cashman will also co-moderate the panel discussion, "Disease Mechanisms in Alzheimer's and Parkinson's Diseases," which will highlight efforts to deepen understanding of the detailed mechanisms involved in these diseases.
AD/PD 2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, takes place in Lisbon, Portugal from March 26-31, 2019. For more information or to register, please visit the AD/PD 2019 conference website.
About ProMIS Neurosciences
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SOURCE ProMIS Neurosciences Inc.
Company Codes: OTC-QB:ARFXF, Toronto:PMN