ProMIS Neurosciences Appoints Renowned Neuroscientist, Dr. Rudolph Tanzi, to Scientific Advisory Board
TORONTO and CAMBRIDGE, MA, Dec. 17, 2018 /PRNewswire/ - ProMis Neurosciences, Inc. , Inc. (TSX: PMN); (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics selectively targeting toxic oligomers implicated in the development of neurodegenerative diseases, today announced the appointment of Rudolph Tanzi, Ph.D, to the Company's scientific advisory board (SAB). Dr. Tanzi is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University and Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-Director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital.
"We are excited that Dr. Rudy Tanzi has joined our scientific advisory board," stated Eugene Williams, ProMIS Executive Chairman. "As an expert clinical scientist in the field of neurodegenerative disorders, with over three decades of outstanding research accomplishments in Alzheimer's disease (AD), Dr. Tanzi brings an impressive wealth of complementary experience to our SAB. We look forward to his insightful contributions as an advisor to ProMIS."
Commenting on the appointment, Dr. Tanzi stated: "I am delighted to join the SAB and look forward to advising ProMIS Neurosciences as the Company progresses its innovative approach selectively targeting toxic oligomers involved in the development of ALS, Parkinson's disease and Alzheimer's disease. In particular, ProMIS' lead antibody for AD, PMN310, offers an exciting opportunity to evaluate in clinical trials the potential best-in-class profile of this therapeutic candidate against toxic oligomers of amyloid beta".
Dr. Rudolph Tanzi is a neuroscientist and geneticist with scientific expertise in Alzheimer's disease and brain health. He serves as Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and as a Director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital. He is also the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School.
Dr. Tanzi received his B.S. (microbiology) and B.A. (history) at the University of Rochester in 1980 and his Ph.D. (neurobiology) at Harvard Medical School in 1990. He is one of the world's leading scientists in research aimed at preventing and treating Alzheimer's disease. His research studies and books have also focused on preserving and promoting brain health. In his research achievements, Dr. Tanzi served on the team that was the first to find a disease gene ((Huntington's disease) using human genetic markers, helping to launch the field of neurogenetics. Dr. Tanzi went on to identify all three early-onset familial Alzheimer's disease genes: the amyloid precursor protein and presenilins 1 and 2. As leader of the Cure Alzheimer's Fund Alzheimer's Genome Project, he has identified several other Alzheimer's disease genes, including the first shown to causing neuroinflammation in Alzheimer's disease (CD33). Dr. Tanzi also discovered the Wilson's disease gene and several other neurological disease genes.
Dr. Tanzi and his team have used Alzheimer's genes and human stem cells to create "Alzheimer's-in-a-Dish" - a three-dimensional human stem cell-derived neural culture system that was the first to recapitulate both pathological hallmarks of Alzheimer's disease: plaques and tangles. This model has made drug screening for Alzheimer's disease considerably faster and more effective. Using this system, Dr. Tanzi has developed several novel therapies for AD including gamma secretase modulators aimed at plaque pathology. These promising drugs are now heading into clinical trials in Alzheimer's disease. Most recently, Dr. Tanzi and his team have discovered that beta-amyloid, the main component of senile plaques, may play a role in the innate immune system of the brain operating as an anti-microbial peptide, suggesting a possible role for infection in the etiology and pathogenesis of AD.
Dr. Tanzi has published over 500 research papers and has received the highest awards in his field, including the Metropolitan Life Foundation Award, Potamkin Prize, Ronald Reagan Award, Silver Innovator Award, and the Smithsonian American Ingenuity Award, the top national award for invention and innovation. He serves on dozens of editorial boards and scientific advisory boards and was named to TIME magazine's list of TIME100 Most Influential People in the World. He also co-authored the books Decoding Darkness, and the three international bestsellers, Super Brain, Super Genes, and The Healing Self. Dr. Tanzi is also a musician who professionally records and performs (keyboards), most recently with Joe Perry and Aerosmith.
About the ProMIS Scientific Advisory Board
The ProMIS SAB brings together a multidisciplinary group of specialists in Alzheimer's disease and neurodegenerative disease along with experts in neurotoxic, prion-like misfolded proteins. In addition to Dr. Tanzi, the current members of the Company's SAB include:
About ProMIS Neurosciences, Inc.
For further information about ProMIS Neurosciences, please consult the Company's website at: www.promisneurosciences.com
The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company's current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
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SOURCE ProMIS Neurosciences Inc.
Company Codes: OTC-QB:ARFXF, Toronto:PMN