Promethera Biosciences Presents Novel Data on HepaStem’s Ability to Reduce Key Disease Parameters in Advanced Stage NASH in vivo Model
Published: Apr 12, 2018
In the current study, the NASH STAM™ model for advanced stage NASH was used to evaluate the therapeutic effect of the liver-derived cell-based treatment HepaStem. The data showed a significant and dose-dependent decrease in the commonly used NAFLD activity score (NAS) following one (22.4% NAS reduction) or three intravenous injections of HepaStem (32.6% NAS reduction versus the control arm). This effect was mainly attributed to a significant reduction in inflammation, thus supporting the proposed mechanism of action of HepaStem.
“As Promethera continues to pioneer the application of cell therapy for the treatment of chronic liver disorders, it is very encouraging to see that HepaStem was able to reduce established disease parameters in preclinical models for both early and now also advanced stages of NASH. Overall, the data we have generated so far in NASH in addition to the safety and tolerability data in pediatric patients with metabolic disorders justify the evaluation in additional phase I/II studies including also more severe NASH patients,” commented Etienne Sokal, M.D., PhD, Chief Innovation and Scientific Officer of Promethera.
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About Promethera Biosciences
Promethera Biosciences is a global innovator in liver therapeutics whose mission is to enable patients to overcome acute and chronic liver diseases. Our lead clinical program, derived from our patented cell technology platform HepaStem, is designed to benefit from its immune-modulatory and anti-fibrotic properties. In addition to our cell-based pipeline we develop antibody technologies, such as the anti-TNF-R1 antibody Atrosimab, to complement and diversify our therapeutic options. We are a team of international experts operating out of R&D and GMP facilities in Mont-Saint-Guibert, Belgium, and Durham, NC, USA.
Promethera®, HepaStem®, H2stem®, Cytonet®, Heparesc® are all registered trademarks of the PROMETHERA group.
Source: Promethera Biosciences