Osiris Release: Peer-Reviewed Publication On The Use Of Grafix Prime For Outpatient Management Of Complex Wounds With Exposed Bone, Tendon, Muscle, Joint, And Hardware
Published: Nov 01, 2016
COLUMBIA, Md., Oct. 31, 2016 (GLOBE NEWSWIRE) -- Osiris Therapeutics, Inc. (NASDAQ:OSIR), a leading regenerative medicine company focused on developing and marketing products for wound care, orthopaedics and sports medicine, announced today that a new peer-reviewed manuscript by Kazu Suzuki, DPM, CWS, Surgeon, Certified Wound Care Specialist, “Viable intact cryopreserved human placental membrane for a non-surgical approach to closure in complex wounds” has been published in the Journal of Wound Care and available on line
A 10-month, single-center effectiveness review was conducted on the clinical outcomes in patients treated with Grafix® for complex wounds characterized by exposed bone, tendon, muscle, or hardware. Wounds were managed with routine standard of care in addition to serial applications of Grafix®. Wound types included chronic wounds, surgical dehiscences and pressure ulcers. The average baseline wound area and duration at presentation were 17.5 cm2 and 11.2 weeks, respectively.
- All cases resulted in granulation over the exposed structures followed by complete wound re-epithelialization without the concomitant use of negative pressure wound therapy (NPWT), hyperbaric oxygen therapy, or surgical intervention
- The mean time to closure was 10 weeks with a mean graft use of 8.1 grafts
- The mean 4-week percentage of wound area reduction was 62.5 %. There were no adverse events attributed to the use of Grafix®
Dr. Suzuki remarked, “This shows that complex wounds with exposed bone, tendon, joint, and hardware can be reliably managed with this viable cryopreserved amniotic membrane graft, allowing patients to achieve wound closure on an outpatient basis. This is in contrast to the more invasive surgical methods requiring inpatient hospitalization and donor site morbidity, such of autologous skin grafting and flap procedures. I believe that it is beneficial for both patients and providers to have multiple treatment options.”
Grafix is a cryopreserved placental membrane comprised of an extracellular matrix (ECM) rich in collagen, growth factors and viable cells native to the tissue. Grafix is processed using Osiris' proprietary BioSmart™ technology; it is flexible and conforming and designed for application directly to hard-to-treat acute and chronic wounds, including but not limited to diabetic foot ulcers, venous leg ulcers and thermal burns.
About Osiris Therapeutics
Osiris Therapeutics, Inc., based in Columbia, Maryland, a world leader in researching, developing and marketing regenerative medicine products that improve health and lives of patients and lower overall healthcare costs. Having developed the world’s first approved stem cell drug, the company continues to advance its research and development in biotechnology by focusing on innovation in regenerative medicine – including bioengineering, stem cell research and viable tissue based products. Osiris has achieved commercial success with products in orthopaedics, sports medicine and wound care, including BIO4 ™, Cartiform®, Grafix®, TruSkin ™ and Stravix™.
Osiris, Grafix, Cartiform, TruSkin and Stravix are registered trademarks of Osiris Therapeutics, Inc. and BIO4 is a trademark of Howmedica Osteonics Corp. More information can be found on the company's website, www.Osiris.com.
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For additional information, please contact: Diane Savoie Osiris Therapeutics, Inc. (443) 545-1834 OsirisPR@Osiris.com