OSE Immunotherapeutics New Immune Checkpoint Inhibitor OSE-172 (Effi-DEM) At The 24th Molecular Med TRI-CON 2017 Meeting Session "Cancer Immunotherapy"

Nantes, February 21, 2017, 6:00 p.m. - OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnémo: OSE) announced today that the company has been invited to present its SIRP-a antagonist OSE-172 (Effi-DEM), and its main preclinical results at the 24th Molecular Med TRI-CON 2017 Meeting, session "Cancer Immunotherapy" in San Francisco (CA) on February 20-22, 2017.

OSE-172 (Effi-DEM) is a humanized monoclonal antibody targeting SIRP-a expressed on suppressive cells involved in the tumor micro-environment (Myeloid cells, named Myeloid Derived Suppressive Cells and Tumor Associated Macrophages).

OSE-172 is an antagonist of SIRP-a which transforms these suppressive cells into effector cells, in particular it inhibits macrophages M2 pro-tumorigenic cells and increases M1 anti-tumorigenic cells. In addition, OSE-172 does not bind human T-cells (does not bind SIRP-y expressed on T-cells), allowing strong effector T-cell proliferation. This original mechanism of action provides reduction of tumor growth in various solid tumor models through such an immune-cell transformation in the tumor micro-environment. As an example, the combination of OSE-172 with anti-PD-L1 is very effective allowing effector macrophages and T-cells to work together at tumor level.

"Our vision is to become a leader with our SIRP-a antagonist in the very attractive and competitive new field of myeloid suppressive cells and tumor associated macrophages. The interest of the blockade on such cells is today increasing as these cells are involved in the limits of action related to T-cell checkpoint inhibitors", said Bernard Vanhove, COO of OSE Immunotherapeutics, in charge of R&D and International scientific collaborations.


February 20-22, 2017 - Moscone North Convention Center, San Francisco


Targeting SIRP-a to Control Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages

Bernard Vanhove, Ph.D., COO, OSE Immunotherapeutics


Our ambition is to become a world leader in activation and regulation immunotherapies

OSE Immunotherapeutics is a biotechnology company focused on the development of innovative immunotherapies for immune activation and regulation in the fields of immuno-oncology, auto-immune diseases and transplantation. The company has a balanced portfolio of first-in-class products with a diversified risk profile ranging from clinical phase 3 registration trials to R&D:

In immuno-oncology:

• Tedopi® (OSE-2101), a combination of 10 optimized neo-epitopes to induce specific T activation in immuno-oncology - Currently in registration Phase 3 trial advanced NSCLC HLA A2+ patients EU /US - Orphan Status in the US - Registration expected in 2019 - A Phase 2 with Tedopi® in combination with a checkpoint inhibitor in NSCLC is considered in 2017.

• OSE-172 (Effi-DEM), new generation checkpoint inhibitor targeting the SIRP-a receptor - In preclinical development for several cancer models.

In auto-immune diseases and transplantation:

• FR104, CD28-antagonist in immunotherapy - Phase 1 trial completed - For the treatment of autoimmune diseases and for use with transplantation - Licensed to Janssen Biotech Inc. to pursue clinical development.

• OSE-127 (Effi-7), interleukin receptor-7 antagonist - In preclinical development for inflammatory bowel diseases and other autoimmune diseases. License option agreement with Servier for the development and commercialization. The portfolio's blockbuster potential gives OSE Immunotherapeutics the ability to enter global agreements at different stages of development with major pharmaceutical players.

Immunotherapy is a highly promising and growing market. By 2023 Immunotherapy of cancer could represent nearly 60% of treatments against less than 3% at present * and the projected market is estimated at $67 billion in 2018 **.

There are more than 80 autoimmune diseases that represent a significant market including major players in the pharmaceutical industry with sales towards $10 billion for the main products. The medical need is largely unmet and requires the provision of new innovative products involved in the regulation of the immune system.

Back to news