Orphagen Pharmaceuticals Awarded Federal Grant for Adrenocortical and Prostate Cancer
Published: Aug 10, 2010
“Orphagen has had a long-term interest in developing a new class of therapeutic small molecules for treatment of endocrine cancers such as adrenocortical and prostate cancer. We’ve now reached the point of generating proof-of-principle data with these new compounds, and the NCI funding will be critical to our progress in the area. We’re also extremely proud of the fact that the program has survived the rigorous peer review necessary to receive this award,” said Scott Thacher, Ph.D., CEO and Founder of Orphagen.
The description of the proposed research reads in part: “Orphagen has identified antagonists to an orphan receptor that regulates the major biosynthetic steps of steroid hormone synthesis in the adrenal cortex and gonads. Safe and effective inhibition of adrenal steroid synthesis has a number of potential applications in oncology, including treatment of two rare and very poorly managed conditions. One is life-threatening, uncontrolled glucocorticoid and/or mineralocorticoid release from metastatic adrenocortical carcinoma (ACC). The other is Cushing’s syndrome resulting from unresectable ACTH-secreting tumors that stimulate adrenal steroid synthesis without normal hypothalamic feedback. In addition, these novel orphan receptor antagonists are potentially of significant value in the treatment of hormone-dependent prostate cancer as chemical castration does not block release of the adrenal androgens, DHEA and DHEA-S, which contribute significantly to the total androgen load in prostate. The novel approach of specifically antagonizing this critical orphan receptor has the potential to be both safer and more effective than mitotane, ketoconazole and aminoglutethimide, broad spectrum P450 inhibitors currently used for this purpose.”
Orphagen identifies and characterizes small molecule drug-like compounds to orphan nuclear receptors. Leveraging academic biological research, we use these compounds to validate the receptors as novel drug targets, establishing first-in-class discovery research programs that are highly attractive to pharmaceutical industry partners.
© Orphagen Pharmaceuticals www.orphagen.com For more information contact: Scott Thacher Ph.D., CEO 11494 Sorrento Valley Road San Diego, CA 92121 (858) 481-6191