Ophthotech Completes Patient Recruitment in the Phase 2a Clinical Trial of Zimura® in Combination with Anti-VEGF Therapy in Wet Age-Related Macular Degeneration
Published: May 01, 2018
“We are pleased with the enthusiasm shown by the principal investigators in the recruitment for this clinical trial leading to on time enrollment of patients,” stated Kourous Rezaei, M.D., Chief Medical Officer of Ophthotech. “Following the completion of this trial, clinical data will be analyzed to assess whether to proceed to a randomized, sham controlled clinical trial of Zimura combination therapy in wet AMD.”
Zimura is also currently being investigated as monotherapy in a Phase 2b clinical trial for patients with geographic atrophy secondary to dry AMD and in a Phase 2b clinical trial in patients with autosomal recessive Stargardt disease (STGD1). Further, Zimura is being evaluated as combination therapy with Eylea® (aflibercept), an anti-VEGF agent, in patients with idiopathic polypoidal choroidal vasculopathy (IPCV).
About Zimura in Wet AMD
Zimura is designed to target and inhibit the complement protein C5. Zimura binds to and inhibits C5 from being cleaved into C5a and C5b, potentially preventing the formation of inflammasomes and the accumulation of membrane attack complex (MAC), preventing cell death. Further, when used in combination with anti-VEGF therapy, Zimura may counteract the anti-VEGF induced complement upregulation, thereby providing the rationale as a potential combination therapy for patients with wet AMD and IPCV.
About Ophthotech Corporation
Ophthotech is a science-driven biopharmaceutical company specializing in the development of novel therapies to treat ophthalmic diseases, with a focus on age-related and orphan retinal diseases. For more information, please visit www.ophthotech.com.
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Source: Ophthotech Corporation