NanoString Announces New Products to Advance COVID-19 Disease Research
Rapid and reproducible spatial analysis of clinically relevant tissue samples is challenging due to the fixation processes required to prevent disease transmission and represents a current unmet need in the market. The COVID-19 GeoMx-formatted Antibody Panel, from Abcam, provides a customizable panel which will be run with the GeoMx Immune Profiling Core to enable spatial analysis of 96 proteins involved in the immune response to SARS-CoV-2 infection. The product was developed to provide optimal results from challenging FFPE tissue samples and is currently available through the GeoMx Technology Access Program.
The GeoMx COVID-19 Immune Response Atlas profiles spatial analysis of over 1,800 genes including receptor, protease, and viral markers associated with COVID-19 disease as well as a broad array of immune markers. Using RNAscope® probes, from Advanced Cell Diagnostics, alongside the GeoMx COVID-19 Immune Response Atlas for visualization, further enables the spatial analysis of cellular and molecular host responses. This product is currently in early access at several key research institutes and is expected to be available later this year.
“An increasing number of recent COVID-19 nCounter publications highlight the benefits of the rapid and reproducible results generated by NanoString’s nCounter and GeoMx platforms for studying the host response to pathogen infection,” said Joe Beechem, CSO and SVP of R&D NanoString Technologies. “The combination of these new products enables the broadest characterization of host response for either bulk or spatial studies and superior performance in clinically relevant samples such as FFPE.”
The nCounter Host Response Gene Expression Panel and COVID-19 Panel Plus spike-in were designed in collaboration with global leaders in infectious disease biology and host-response. The Host Response Gene Expression Panel includes 770 genes focused on host susceptibility, interferon signaling, innate and adaptive immunity as well as other key areas of biology to characterize host response to infection. The COVID-19 Panel Plus spike-in contains probes targeting all SARS-CoV-2 genes as well as the host ACE receptor that is bound by the virus. The new Host Response Panel can be combined with the COVID-19 Panel Plus spike-in or custom content, enabling researchers to characterize the host and viral genes simultaneously.
About NanoString Technologies, Inc.
NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company’s nCounter® Analysis System is used in life sciences research and has been cited in more than 3,300 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company’s GeoMx® Digital Spatial Profiler enables highly-multiplexed spatial profiling of RNA and protein targets in a variety of sample types, including FFPE tissue sections.
For more information, please visit www.nanostring.com.
NanoString, NanoString Technologies, the NanoString logo, GeoMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc. in various jurisdictions. RNAscope is a registered trademark of Advanced Cell Diagnostics.
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Source: NanoString Technologies, Inc.