Microbion Corporation Receives Additional Funding Support from the Cystic Fibrosis Foundation to Speed Advancement of Inhaled Pravibismane
BOZEMAN, Mont. and VANCOUVER, BC, Feb. 22, 2021 /PRNewswire/ -- Microbion Corporation of Bozeman, MT, and Microbion Pharma Corp. of Vancouver, BC ("Microbion") today announced that it has received additional funding from the Cystic Fibrosis Foundation to speed the advancement of inhaled pravibismane for the treatment of cystic fibrosis (CF) related pulmonary infections. This new funding of up to $1.8 million will directly support IND-enabling toxicology studies and is in addition to $5.6 million previously awarded by the Foundation, for a combined total of up to $7.4 million.
"We are excited that the CF Foundation continues to support Microbion's efforts toward bringing inhaled pravibismane forward to the clinic," said Karim Lalji, Chairman and CEO of Microbion Pharma Corp. "The Foundation's support underscores their commitment to assist companies with valuable, novel therapeutics that potentially improve the quality of life of patients with CF. We look forward to working closely with the Foundation to advance the IND-enabling toxicology studies, targeted for completion in Q2 2021."
Pravibismane is the first in a new class of anti-infective drugs structurally unrelated to other clinically utilized antibiotics. With a novel mechanism of action, pravibismane functions as a microbial bioenergetic inhibitor, shutting down bacterial ATP production and halting all cellular metabolism. In the lab, pravibismane exhibits broad-spectrum, potent, and persistent antimicrobial activity against CF-relevant pathogens including carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa, as well as other multidrug-resistant pathogens. Importantly, pravibismane also exhibits potent activity against the biofilms that these pathogens establish, which have been implicated in the chronic persistence of CF pulmonary infections. Microbion's inhaled pravibismane program is currently also receiving funding support from CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) as previously announced.
For more information visit: www.microbioncorp.com.
Safe Harbor Statement
CARB-X funding for the pravibismane project is sponsored by Cooperative Agreement Number IDSEP160030 from ASPR/BARDA and by awards from Wellcome Trust and Germany's Federal Ministry of Education and Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of CARB-X or any of its funders.
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