Pharmazz Release: Issuance of Patent and Initiation of a Study to Evaluate PMZ-1620 in Dogs With Degenerative Myelopathy, a Disease Similar to Human Amyotrophic Lateral Sclerosis (ALS)
NAPERVILLE, Ill., Jan. 11, 2018 /PRNewswire/ -- Pharmazz, Inc. is pleased to announce that Indian Patent No. 290038 on a pharmaceutical composition comprising IRL-1620 (PMZ-1620) was granted on November 28, 2017. PMZ-1620, a selective endothelin-B receptor agonist, is presently undergoing clinical studies in patients suffering from mild to moderate Alzheimer's disease. In addition, a phase II study, using PMZ-1620, is being conducted in patients with cerebral ischemic stroke.
The company also announces the initiation of a study to evaluate PMZ-1620 in dogs with degenerative myelopathy. Degenerative myelopathy is a spinal cord disease of dogs, progressing from weakness of the hind-limbs to eventual paralysis. In many ways, degenerative myelopathy has pathological, genetic and clinical features similar to human amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Currently, there are no effective treatment options to arrest or reverse degenerative myelopathy or ALS. The Institute for Healthcare Innovation, College of Veterinary Medicine, and Chicago College of Pharmacy at Midwestern University are collaborating on a new study to evaluate PMZ-1620 in dogs with degenerative myelopathy. The peptide, PMZ-1620, has been the subject of Dr. Gulati's research at Chicago College of Pharmacy and known to have neurogenic properties, a mechanism which may have applications for degenerative myelopathy. Pharmazz, Inc. has exclusive rights to PMZ-1620 from Midwestern University and plans to initiate studies in patients with amyotrophic lateral sclerosis if the results of this study in dogs with degenerative myelopathy are positive.
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