Ipsen Announces Analysis Of Managed Medicaid Data Of Children With Cerebral Palsy At Annual Meeting Of The American Academy Of Cerebral Palsy And Developmental Medicine

BASKING RIDGE, N.J.--(BUSINESS WIRE)--Ipsen Biopharmaceuticals, Inc., an affiliate of Ipsen (Euronext: IPN; ADR: IPSEY) (Ipsen), today announced a presentation of data from a retrospective study on managed Medicaid costs of treating children with Cerebral Palsy (CP) at the annual meeting of the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) on September 13-16, 2017 in Montreal, Canada. This data evaluated recent, large-scale, landscape studies of the burden of illness for CP patients in the U.S.

Cerebral Palsy is a term for a group of neurological disorders that appear in infancy or early childhood and affect the part of the brain that controls muscle movements.¹ One of the symptoms associated with CP is spasticity – a condition in which there is an abnormal increase in muscle tone or stiffness in one or more muscles.²

The study objective was to better understand the epidemiology, treatment patterns, resource utilization and associated costs of children with CP in the U.S. Managed Medicaid data from a proprietary database covering 15 states and encompassing seven million lives between 2013-2015 was analyzed, with 3,294 unique cases, which represent patients with CP (aged 2-20) identified through ICD-9/10 diagnosis codes.

The analysis indicates that 42 percent of children diagnosed with CP did not receive any of 10 selected therapies commonly used for spasticity management; these therapies included physical therapy, orthotics, oral baclofen, botulinum toxin, anti-spasm medication, casting, orthopedic surgery, baclofen injection, baclofen pumps, and rhizotomies. These therapies were selected by a group of multidisciplinary researchers and care team members who determined that these methods were the most commonly used spasticity management options for CP patients.

The data also showed the average annual cost of treatment for a child with CP was about 16 times higher than the average cost of treatment for any child enrolled in Medicaid ($22,383 versus $1,359, respectively) between the years 2013 and 2015. Annual costs included expenditure from utilization of pharmacy, medical services, home health, long term care and hospice. Because CP disease severity cannot be obtained from diagnosis codes, the study team developed clinical algorithms to assess the likelihood of ambulation among CP children; 30.5 percent were identified as likely ambulatory, 33.8 percent as likely non-ambulatory, and the remainder unknown. Children with CP that were likely non-ambulatory had average annual costs four times higher than those for children with CP who were likely ambulatory. There was large variability in the medical expenditure for children with CP, even for those with the same ambulatory status. This may be driven in part by regional Medicaid coverage differences. Limitations of this retrospective study include incomplete or inaccurate submitted claims. Further research is needed to understand the specific cost drivers associated with the care of children with CP.

“This study supports the need for a broader look into the overall management plans for children living with Cerebral Palsy, including appropriate treatment options and physical and occupational therapies. We hope this would also lead to better management of costs for families,” said David Cox, VP North American Medical, HEOR & Regulatory Affairs, Ipsen. “Ipsen is committed to improving the care of children with lower limb spasticity – especially those with Cerebral Palsy, the most common motor disability in children.³”

About Ipsen in North America

Ipsen Biopharmaceuticals, Inc. is the US affiliate of Ipsen, a global specialty-driven pharmaceutical group. The US head office is located in Basking Ridge, New Jersey. Ipsen Biopharmaceuticals Canada, Inc. is an integrated business unit within North America and has its head office located in Mississauga, Ontario. Ipsen Bioscience, Inc., the Ipsen US research and development center focused on peptide research in oncology and endocrinology, is located in Cambridge, Massachusetts. At Ipsen Bioscience, we focus on creating a highly cooperative and passionate R&D organization through partnerships, innovation, and continuous learning to effectively deliver new treatments for patients. At Ipsen, we focus our resources, investments, and energy on discovering, developing, and commercializing new therapeutic options for oncologic, neurologic, and endocrine diseases. For more information on Ipsen in North America, please visit www.ipsenus.com or www.ipsen.ca.

About Ipsen

Ipsen is a global specialty-driven biopharmaceutical group focused on innovation and specialty care. The group develops and commercializes innovative medicines in three key therapeutic areas - Oncology, Neurosciences and Rare Diseases. Its commitment to oncology is exemplified through its growing portfolio of key therapies for prostate cancer, neuroendocrine tumors, renal cell carcinoma and pancreatic cancer. Ipsen also has a well-established Consumer Healthcare business. With total sales close to €1.6 billion in 2016, Ipsen sells more than 20 drugs in over 115 countries, with a direct commercial presence in more than 30 countries. Ipsen's R&D is focused on its innovative and differentiated technological platforms located in the heart of the leading biotechnological and life sciences hubs (Paris-Saclay, France; Oxford, UK; Cambridge, US). The Group has about 5,100 employees worldwide. Ipsen is listed in Paris (Euronext: IPN) and in the United States through a Sponsored Level I American Depositary Receipt program (ADR: IPSEY). For more information on Ipsen, visit www.ipsen.com.

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References:
		1.		National Institute of Neurological Disorders and Stroke. NINDS Cerebral Palsy Information Page. https://www.ninds.nih.gov/Disorders/All-Disorders/Cerebral-Palsy-Information-Page. Accessed September 12, 2017
		2.		National Institute of Neurological Disorders and Stroke. Spasticity Information Page. https://www.ninds.nih.gov/Disorders/All-Disorders/Spasticity-Information-Page. Accessed September 12, 2017.
		3.		Centers for Disease Control and Prevention: Data & Statistics for Cerebral Palsy. http://www.cdc.gov/ncbddd/cp/data.html. Accessed May 2, 2016.

© 2017 Ipsen Biopharmaceuticals, Inc.
September 2017 DYS-US-002203