GI Dynamics Release: IK+EM Study Released At EASD Shows Similar Outcomes Between Gastric Plication And Endobarrier
Published: Sep 25, 2017
LISBON, Portugal--(BUSINESS WIRE)--GI Dynamics®, Inc. (ASX:GID), a medical device company that has commercialized EndoBarrier® in Europe, the Middle East and South America for patients with type 2 diabetes and obesity, announces that new data has been released from the Institute for Clinical and Experimental Medications (“IK+EM”) on the comparison of 40 patients who underwent either gastric plication or EndoBarrier treatment or were control patients. The IK+EM released the data at the 53rd Annual Meeting of the European Association for the Study of Diabetes (“EASD”).
“Circulating Lipopolysaccharide and Gut Permeability in Obese Subjects with Type 2 Diabetes: The Influence of Surgical and Endoscopic Interventions”
Dr. Anna Cinkajzlova, from the Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine presented “Circulating Lipopolysaccharide and Gut Permeability in Obese Subjects with Type 2 Diabetes: The Influence of Surgical and Endoscopic Interventions” the analysis of which compared gastric plication to EndoBarrier. Dr. Cinkajzlova, on behalf of the team led by Professor Haluzik, selected 40 patients from their registry who met the criteria to be in one of three subject groups. Of the 40 patients, 30 had type 2 diabetes mellitus (“T2DM”) and obesity and the remaining 10 were healthy control patients. The 30 patients with T2DM and obesity were divided into two groups of 15. Group one underwent surgical gastric plication (“GP”) with measurement points at baseline (treatment) and at one and six-months post-treatment. Group two were implanted with EndoBarrier, with measurement points at baseline (implant), and at one month and ten months (at EndoBarrier explant).
The analysis conducted a basic science assessment of circulatory levels of lipopolysaccharide binding protein, fatty acid binding protein 2 and sCD14 following assigned weight-reducing treatments combined with quantification of adipose tissue macrophages. In addition, the study compared the clinical outcomes across multiple health metrics and biomarkers between surgical gastric plication, a form of gastric restriction, and EndoBarrier.