Fujifilm Diosynth Biotechnologies Chooses ambr250 System For Optimising Microbial Fermentation

Published: Sep 16, 2014

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To Rapidly Develop Robust Scale-up Processes for Biopharmaceutical Production

Cambridge, UK: TAP Biosystems (now part of the Sartorius Stedim Biotech Group), a leading supplier of innovative cell culture and fermentation systems for life science applications, is pleased to announce that its ambr250™ automated mini bioreactor system is being successfully used at leading Contract Development and Manufacturing Organisation, FUJIFILM Diosynth Biotechnologies, for optimising their microbial fermentations to accelerate scale-up production of protein-based therapeutics.

Fujifilm’s scientists at Billingham in the UK are using the ambr250 system, with its independent parallel control of 24, single-use 250mL mini bioreactors in their state-of-the-art process development facility to fully evaluate process characteristics of large scale fermenters. The researchers have seen equivalent growth and protein expression profiles when comparing 20L fermenters and the ambr250 mini bioreactors for culturing E.coli and P. pastoris strains expressing a number of model proteins.

Scientists at Fujifilm are also using the ambr250 for DoE (design of experiments) with microbial fermentations saving cleaning and sterilising time by “replacing reusable steam in place” benchtop bioreactors with this system. Combining the ambr250’s high-throughput capabilities and single-use technology is thus allowing Fujifilm’s scientists to develop and scale-up processes more rapidly.

Dr Simon Dewar, Head of R&D Upstream Operations at FUJIFILM Diosynth Biotechnologies commented: “The ambr250 is at the forefront of microbial fermentation technology. In my 25 years as a fermentation professional, it is the only scale-down fermenter system I’ve seen that is so well executed that it changes everything. Pharma and biotech clients, whom we are developing biological production processes for, see the ambr250 system and realise how much it will advance their process understanding and allow rapid scale-up to manufacturing.”

Mwai Ngibuini, ambr250 Product Manager at TAP Biosystems added: “We’re delighted that such a leading CDMO is using ambr250 so successfully to accelerate process development of protein-based therapeutics. Their research indicates that using the ambr250 system for high-throughput, microbial and mammalian culture scale-up is an intelligent strategy.”


For Further Information Contact:

Michaela McAdam, Marketing Communications Executive, TAP Biosystems, York Way, Royston, Hertfordshire, SG8 5WY, UK. Tel: +44 (0) 1763 227200
Fax: +44 (0) 1763-227201 Email: Michaela.mcadam@tapbiosystems.com
Web: www.tapbiosystems.com Twitter: @TAPBiosystems

Dr Simon Dewar, Head of R&D Upstream Operations, FUJIFILM Diosynth Biotechnologies, Belasis Avenue, Billingham, TS23 1LH, UK.
Tel: +44 (0)1642 364040
Email: simon.dewar@fujifilmdb.com Web: www.fujifilmdiosynth.com
Editor Contacts:
Dr Sue Pearson, Director, International Science Writer, PO Box 170, Hitchin, Hertfordshire, SG5 3GD, UK.
Tel/Fax + 44 (0) 1462-635327 Email: sue.pearson@internationalsciencewriter.com
Web: www.internationalsciencewriter.com Twitter: @isciencewriter

Bridget Hall, Communications Manager, FUJIFILM Diosynth Biotechnologies, Belasis Avenue, Billingham, TS23 1LH, UK.
Tel: +44 (0)1642 367320 Mobile: +44 (0)7796 938929
Email: bridget.hall@fujifilmdb.com Web: www.fujifilmdiosynth.com

Note to Editors
About TAP Biosystems

TAP Biosystems (now part of the Sartorius Stedim Biotech Group) is a leading global provider of automated cell culture and fermentation systems for life science research, development and production. TAP's systems are in use worldwide at pharmaceutical, biotechnology and academic laboratories, supporting bioprocess development and GMP manufacture of biologics and cell therapies, as well as discovery and stem cell research programmes.

Founded in 1987, the company has offices in the UK and USA, and an extensive network of distributors in Europe and Asia offering pre- and post-sales support. www.tapbiosystems.com

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