Clear Creek Bio Doses First Patient in Phase 2 Outpatient Study of Brequinar to Treat COVID-19
“There’s an exceptional need for oral antiviral treatments that are suitable for outpatient treatment, and we are pleased to advance brequinar into a Phase 2 clinical trial for the treatment of COVID-19,” said Vikram Sheel Kumar, M.D., Chief Executive Officer of Clear Creek Bio. “We believe brequinar’s unique drug profile, with oral bioavailability and high potency, supports its development as an oral, once-daily treatment for COVID-19.”
“In addition to its demonstrated in vitro antiviral activity against SARS-CoV-2, brequinar has been previously studied in more than 1,000 patients for other medical conditions,” said John C. Pottage, Jr., M.D., Chief Medical Advisor of Clear Creek Bio. “The purpose of this clinical trial is to establish whether brequinar has the antiviral safety and tolerability profile in patients infected with SARS-CoV-2 that can support the further clinical development of brequinar for the treatment of COVID-19.”
For more info on the clinical trial, please visit https://clinicaltrials.gov/ct2/show/NCT04575038.
About Clear Creek Bio
Clear Creek Bio is a private biotech company focused on developing novel therapies to address infectious disease and cancer. The company’s lead drug candidate, brequinar, is a dihydroorotate dehydrogenase (DHODH) inhibitor with high potency and short half-life. In addition to its potential as a broad spectrum antiviral, the company is evaluating brequinar as a potential treatment for acute myeloid leukemia. For more information, please visit www.clearcreekbio.com.
- Rui Xiong, et al. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. August 2020. https://doi.org/10.1007/s13238-020-00768-w
Source: Clear Creek Bio, Inc.