Bolder BioTechnology, Inc. Announces $600,000 Grant from National Institutes of Health (NIH) to Study Long-Acting IL-11 Analog in Treating Acute Radiation Syndrome
Published: Aug 18, 2010
"Development of radiological/nuclear countermeasures to treat ARS is a high priority research area for NIAID," said George (Joe) Cox, Ph.D., Company President and Principal Investigator for the grant. "We are delighted to receive a grant award from NIAID to conduct research with our long-acting IL-11 analog in ARS."
Bone marrow is one of the most sensitive tissues to radiation damage and impaired production of blood cells is one of the first clinical signs of excessive radiation exposure, often resulting in death. IL-11 is a protein that stimulates bone marrow cells to divide and differentiate into platelets. Recent studies indicate that IL-11 can mitigate some of the hematopoietic and gastrointestinal complications of radiation exposure and improve survival in animal models of ARS. IL-11 has a short half-life in humans, which necessitates daily dosing, and may not optimize therapeutic benefits of the protein for patients. A long-acting IL-11 analog that does not require frequent dosing could provide significant treatment advantages in a nuclear emergency setting.
The NIH SBIR program is a peer-reviewed grant program that provides research support to small businesses to discover and develop innovative biomedical products for the treatment of serious unmet medical needs.
Bolder BioTechnology, Inc. uses advanced protein engineering technologies to create proprietary human protein pharmaceuticals with enhanced therapeutic properties for the treatment of hematopoietic and endocrine disorders, cancer and infectious diseases.
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SOURCE Bolder BioTechnology, Inc.