Akebia Therapeutics, Inc. Announces Initiation of Phase 2b Trial of Oral Anemia Candidate

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CINCINNATI--(BUSINESS WIRE)--Akebia Therapeutics, a biotech company focused on developing and commercializing small molecules to treat anemia and cancer, today announced that it has dosed the first patient in the Phase 2b trial of AKB-6548 for the treatment of anemia associated with chronic kidney disease (CKD). AKB-6548 is an orally available, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, which is designed to stabilize HIF2a, a critical regulator of red blood cell production and iron absorption. By working in this manner, AKB-6548 achieves a very controlled and natural stimulation of red blood cell production that is similar to the effect of modest increases in altitude.

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