Light Activated Nanoballoons Open Inside Tumors To Release Chemo Cargo, University at Buffalo Study

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Targeted delivery of chemotherapy may help overcome the terrible side effects that injecting poison into the whole body can have. A team of researchers headed by scientists at University of Buffalo have developed new nanoscale liposomes, made out of lipids, that can ferry chemo without spilling a drop until a near-infrared laser illuminates them. The nanoscale vesicles are made of porphyrin-phospholipid (PoP) liposomes, but the mechanism of them popping open to release the cargo is yet to be explained. Nevertheless, the team tested the nanoballoons in laboratory mice and found that they open up inside the animals exactly where the laser was directed, and, once it’s turned off, the liposomes close and sequester a good amount of surrounding molecules that may be related to the progression of the cancer.

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