CicloMed Announces Presentation of Preclinical Evidence for its Bladder Cancer Agent at AACR 2018 Meeting
Published: Jun 06, 2018
CicloMed LLC, a biotechnology company developing novel treatments for bladder cancer, today announced the presentation of preclinical evidence supporting Ciclopirox Prodrug (CPX-POM), its anti-cancer agent currently in Phase I clinical trials, at the American Association for Cancer Research (AACR) 2018 Annual Meeting in Chicago.
Scott J. Weir, Pharm.D, Ph.D., Associate Director – Translational Research at The University of Kansas Cancer Center, will present a poster entitled “Bench-to-bedside translation of ciclopirox prodrug for the treatment of non-muscle invasive and muscle-invasive bladder cancer,” from 8 a.m. to noon Wednesday April 18 (Abstract No. 5882 / 29; Poster Section 39, Exhibit Hall A, McCormick Center South). The abstract is available through the AACR website at http://www.abstractsonline.com/pp8/#!/4562/presentation/6744.
“The poster at AACR 2018 summarizes preclinical proof of principle data for Ciclopirox Prodrug supporting investigation of this agent as a potential treatment in bladder cancer. Based on evidence presented at AACR and other data, CicloMed is now conducting a first-in-human clinical trial of CPX-POM to characterize its safety, dose tolerance, pharmacokinetics and pharmacodynamics in patients with advanced solid tumors. We look forward to reporting further progress,” said Tammy Ham, President and Chief Executive Officer of CicloMed LLC.
The Ciclopirox Prodrug poster describes evidence generated from in vitro experiments on high-grade human bladder cancer cell lines, as well as in vivo preclinical studies conducted in a validated mouse model of bladder cancer. The evidence Dr. Weir will present suggests Ciclopirox Prodrug inhibits progression of non-muscle invasive to muscle-invasive bladder cancer.
Ciclopirox Prodrug was discovered by scientists at The University of Kansas Cancer Center and KU’s Institute for Advancing Medical Innovation (IAMI). CicloMed was formed as a public-private partnership between BioNOVUS Innovations LLC and IAMI in 2016. Development of CPX-POM for the treatment of bladder cancer is the lead development program under this partnership.
“Through our unique public-private partnership, Ciclopirox Prodrug has advanced from the laboratory bench to an ongoing first-in-human Phase I trial in cancer patients,” said Roy Jensen, M.D., Director of The University of Kansas Cancer Center. “The partnership with CicloMed is helping our NCI Cancer Center fulfill its vision to discover and advance promising new cancer treatments to patients.”
More than 500,000 men and women are living with bladder cancer in the United States. Bladder cancer is the fifth most common cancer in Americans and the fourth most common cancer in men. According to the American Cancer Society, about 81,000 new cases of bladder cancer will be diagnosed in 2018, and more than 17,000 deaths are expected this year.
About CicloMed LLC
CicloMed is a developmental-stage pharmaceutical company focusing on unmet medical needs in oncology, and Ciclopirox Prodrug is its lead drug candidate. CicloMed is a subsidiary of BioNOVUS Innovations LLC, a Kansas City-based firm committed to investing in individuals and organizations who are transforming healthcare and bringing novel solutions to reality. Portfolio companies have developed new enabling technologies, pharmaceuticals and delivery models that are transformative. For more information, visit www.ciclomed.com.
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